Comparison of acute toxicities and clinical outcome in locally advanced cervical cancer patients treated with two different radiation techniques.

Active, not recruiting

Conditions: Malignant neoplasm of cervix uteri, unspecified,

Registration Number: CTRI/2020/03/023923

Lead Sponsor: Govt Medical College Patiala

Brief Summary: In Indian setup, there is a major load of cervical cancer patients. Till date, most of our patients were being treated with 3DCRT. Since VMAT planning is time consuming and complex than 3DCRT, our study intends to compare the two conformal techniques in terms of acute toxicities and local response, so that the technique with lesser toxicities and /or better response can be implemented routinely for the treatment of such patients

Detailed Description: Not available

Recruitment & Eligibility

Status: Closed to Recruitment of Participants

Sex: Female

Target Recruitment: 100

Inclusion Criteria

1.Previously untreated, biopsy proven squamous cell carcinoma cervix stage IB2- IIIB.
2.Karnofsky performance scale > 70 (appendix I) 3.Pre treatment parameters :- a)Age â‰¤ 70 years b)HB > 10 gm/dl c)TLC > 4000/cu mm d)Platelets > 1 lakh/cu mm e)Serum urea < 40 mg/dl f)Serum creatinine < 1.2mg/dl g)Normal Chest X-ray 4.Patientâ€Ÿs willingness to give informed consent and agree to follow.

Exclusion Criteria

1.All post operative cases 2.Medical contraindication for concurrent chemotherapY 3.Patients who have received chemoradiotherapy earlier 5.Patients having any uncontrolled co morbid conditions.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Dosimetric comparison of doses to target volumes (PTV, CTV) and OAR (bowel, bone marrow, bladder and rectum) in both the treatment groups.	Assessment done weekly
2. Difference in 2 yr local control rates among the two groups	Assessment done weekly

Secondary Outcome Measures

Name	Time	Method
Acute gastrointestinal and genitourinary toxicities among the two groups	Assessment done weekly

Trial Locations

Locations (1): Government Medical College, Patiala
🇮🇳
Patiala, PUNJAB, India
Government Medical College, Patiala
🇮🇳Patiala, PUNJAB, India
ANSHUMA BANSAL
Principal investigator
9592096223
dranshubansal3@gmail.com