The Risk of Developing Acute Myeloid Leukaemia in Patients With Ewing's Sarcoma: A SEER-based Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,631
- 试验地点
- 1
- 主要终点
- The standardized incidence ratio and excess risk of developing acute myeloid leukemia in Ewing's sarcoma patients
研究概览
简要总结
Ewing's sarcoma is an uncommon yet vital malignancy of bone. It demonstrates a predilection for the pediatric and young adult population. Chemotherapy is considered an important treatment modality for Ewing's sarcoma. However, the development of therapy-related leukemia, especially acute myeloid leukemia following treatment, is attributed to the use of substances such as alkylating agents and topoisomerase inhibitors which are genotoxic. There is a very few studies elaborating on the incidence rates of such complications. So, our aim is to quantify the risk of developing acute myeloid leukemia in Ewing sarcoma patients and provide an updated evidence to the literature.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with Ewing sarcoma
- •Latency exclusion period of 6 months
- •Sequence 0 or 1
排除标准
- •patients lacking age documentation or age reported only on death certificates or autopsies
结局指标
主要结局
The standardized incidence ratio and excess risk of developing acute myeloid leukemia in Ewing's sarcoma patients
时间窗: from Jan, 2000 till Dec, 2021
The surveillance, epidemiology and End Results (SEER) database was used to calculate the standardized incidence ratio (SIR) as Observed/Expected (O/E) and calculated the excess absolute risk for acute myeloid leukemia in Ewing's sarcoma patients.
次要结局
- The standardized incidence ratio and excess risk of second primary malignancies in Ewing's sarcoma patients across different racial groups(from Jan, 2000 till Dec, 2021)
- The standardized incidence ratio and excess risk of second primary malignancies in Ewing's sarcoma patients between different stages(from Jan, 2000 till Dec, 2021)
研究者
asmaa salama ibrahim
Resident physician of gastroenterology
Suez Canal University