Free Walking Exercise in Obstructive Sleep Apnea Patients With Non-alcoholic Fatty Liver

Not Applicable

Recruiting

• Conditions: Obstructive Sleep Apnea; Non-alcoholic Fatty Liver
• Interventions: Behavioral: continuous positive airway pressure; Behavioral: free walking exercise and continuous positive airway pressure

• Registration Number: NCT06508190
• Lead Sponsor: Ahram Canadian University

Brief Summary

Research evaluating the impact of continuous positive airway pressure (CPAP) \& walking exercise on fatigue severity, liver enzymes and sleeping quality in patients with non-alcoholic fatty liver disease who also have obstructive sleep apnea. Forty patients are divided into two groups: twenty patients CPAP and other twenty patients for CPAP and walking program .

Detailed Description

Research evaluating the impact of continuous positive airway pressure (CPAP) \& walking exercise on fatigue severity, liver enzymes and sleeping quality in patients with non-alcoholic fatty liver disease who also have obstructive sleep apnea. Forty patients are divided into two groups: twenty patients CPAP and other twenty patients for CPAP and walking program .

Study Timeline

• Status Verified: 2024-07
• Study Start: 2024-07-12
• Study First Submitted: 2024-07-13
• Study First Submitted QC: 2024-07-13
• Last Update Submitted: 2024-07-13
• Study First Posted: 2024-07-18
• Last Update Posted: 2024-07-18
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• The body mass index (BMI) < 35 kg/m2.
• obstructive sleep apnea patients with fatty liver

Exclusion Criteria

• liver transplantation , alcoholic fatty liver, antipsychotic medications, bariatric surgery; cardiac , renal problem , liver cancer ; pregnancy,orthopedic problems, systemic diseases, respiratory dysfunctions, neurological dysfunctions.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
continuous positive airway pressure therapy	continuous positive airway pressure	The continuous positive airway pressure therapy equipment is used for 12 weeks, all patients in this group groups must utilize the CPAP machine for 4 hours each night.
Free walking & continuous positive airway pressure therapy	free walking exercise and continuous positive airway pressure	Each patient is required to walk 30 minutes, seven days a week for 12 weeks. \& The continuous positive airway pressure therapy equipment is used for 12 weeks, all patients in both groups must utilize the CPAP machine for 4 hours each night.

Primary Outcome Measures

Name	Time	Method
Alanine tranaminase	it will be measured after 12 weeks	serum hepatic enzyme

Secondary Outcome Measures

Name	Time	Method
Pittsiburg sleeping quality index	it will be assessed after 12 weeks	a questionnaire that wil be used for assessing sleeping quality
fatigue severity scale	it will be assessed after 12 weeks	a questionnaire that wil be used for assessing fatigue
Epworth sleepness scale	it will be assessed after 12 weeks	a questionnaire that wil be used for daytime sleepness
Asparatate transamianse	it will be measured after 12 weeks	serum hepatic enzyme
Body mass index	it will be measured after 12 weeks	it will be masusured on empty stomach and bladder
triglycerodes	it will be assessed after 12 weeks	it will be meausred in plasma

Trial Locations

Locations (1)

Ahram canadian university; 🇪🇬 Giza, Egypt