Understanding Hallucinations (Part I) - Phenomenology and Cognition
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hallucinations
- Sponsor
- UMC Utrecht
- Enrollment
- 700
- Locations
- 4
- Primary Endpoint
- The number of clusters of patients with shared symptom profiles as determined by latent class analysis, and the difference in scores on cognitive assessment between these identified clusters.
- Last Updated
- 9 years ago
Overview
Brief Summary
Psychotic symptoms (hallucinations and delusions) are present in several psychiatric and neurological disorders as well as in the general population. Effective treatment strategies for these symptoms in all patients are lacking and treatment-response can presently not be predicted. To date, the exact pathophysiological mechanism of these symptoms remains unknown. By investigating (subtypes) of hallucinations and delusions in all populations, a common pathway may be found, leading to more effective treatment options. Alternatively, different subtypes may be associated with different pathophysiological mechanisms.
Investigators
Iris Sommer
Prof.Dr.
UMC Utrecht
Eligibility Criteria
Inclusion Criteria
- •age \> 18 years
- •mentally competent
- •in case of delirium: family member able to give informed consent
- •Individuals with hallucinations will have to experience at least one episode of hallucinations over the last month.
- •Individuals without hallucinations: no current hallucinations and a history of maximum 1 episode of hallucinations with a maximum duration of 1 week, at least two years ago.
Exclusion Criteria
- •Age \<18)
- •Participants that cannot read, speak or understand Dutch
- •For all included diagnostic groups except delirium: Mentally incompetent individuals who are not capable to provide informed consent, as determined by their treating physician.
Outcomes
Primary Outcomes
The number of clusters of patients with shared symptom profiles as determined by latent class analysis, and the difference in scores on cognitive assessment between these identified clusters.
Time Frame: Three years
Secondary Outcomes
- The internal consistency, test-retest reliability, inter-rater reliability, criterion validity and construct validity of a newly developed questionnaire.(Two years)
- The difference in scores on cognitive assessment between participant groups with and without psychotic symptoms.(Three years)