Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth (A Randomized Controlled Clinical Trial)
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Pulp Necroses
- Sponsor
- Nourhan M.Aly
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Assessment of pulp vitality
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of the present study is to assess clinically and radio-graphically the regenerative potential of immature permanent teeth with necrotic pulp using blood clot and Platelet rich fibrin scaffolds.
Detailed Description
30 immature necrotic permanent teeth in patients will be allocated and divided into two groups. Group 1 will be treated by regenerative procedure using blood clot as a scaffold and Group 2 will be treated with regenerative procedures using combined blood clot and Platelet rich fibrin as a scaffold.
Investigators
Nourhan M.Aly
Teaching Assistant of Dental Public Health and Statistician
University of Alexandria
Eligibility Criteria
Inclusion Criteria
- •Necrotic incisors with immature roots
- •Pulp space not needed for post and core.
- •The patient has to be free from any coagulation disorders, with normal platelets count.
- •Good oral hygiene
- •Cooperative patient
Exclusion Criteria
- •Internal or external root resorption.
- •Root fracture and/or alveolar fracture.
- •Previous root canal treatment.
- •Medically compromised patients
- •Uncooperative patient
Outcomes
Primary Outcomes
Assessment of pulp vitality
Time Frame: 12 months
Pulp vitality will be assessed using thermal and electric pulp sensibility tests
Assessment of the size of periapical radiolucency
Time Frame: 12 months
Size of the lesion will be assessed using Cone Beam Computed Tomography (CBCT).
Subjective pain assessment
Time Frame: 12 months
The patient will be asked about the presence of any pain or discomfort. Pain severity will be categorized as: no pain - mild pain - moderate pain - severe pain
Assessment of root development
Time Frame: 12 months
Continued root development will be assessed using cone beam computed tomography (CBCT) and compared with the contra-lateral healthy tooth