Cognitive and Neural Networks in Psychiatry (CNNP): Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure (ERP in Silico)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Yale-Brown obsessive compulsive scale (Y-BOCS)
研究概览
简要总结
The aim of this study is to understand why patients with obsessive-compulsive disorder (OCD) fail in therapy.
To understand the neural mechanisms involved in exposure therapy that support success and clinical improvement in order to improve therapy outcomes for OCD patients.
详细描述
A course of therapy is recommended for individuals with obsessive-compulsive disorder (OCD). It is usually a type of cognitive behavioural therapy (CBT) with exposure and response prevention (ERP).
In this study the investigators assess patients pre-therapy and post-therapy evaluating symptom severity (measured by the Y-BOCS) and decision-making (measured by online questionnaires and computer-based behavioural tasks).
To examine how decisions are formed in patients undergoing OCD CBT, how behaviour changes after a non-pharmacological therapy module and how it is associated to the alleviation of OCD symptoms.
The study, which will recruit 90 patients, is based at University College London - Wellcome Centre for Human Neuroimaging. This study is a part of the Cognitive and Neural Networks in Psychiatry (CNNP) study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of obsessive-compulsive disorder (OCD)
- •Fluent in written and spoken English
- •Normal/corrected to normal vision
- •Expecting to start OCD therapy
排除标准
- •Autism spectrum disorder, psychosis, schizophrenia, addiction, substance abuse, bipolar, hoarding, or Tourette disorder
- •Hearing conditions: tinnitus, ear inflammation, hearing sensitivity, hearing loss, requires hearing aids
- •Colour blindness
- •Severe learning disabilities
结局指标
主要结局
Yale-Brown obsessive compulsive scale (Y-BOCS)
时间窗: 3 - 9 months
The Y-BOCS is a 10-item scale used to assess symptom severity in OCD.
Decision making and learning tasks
时间窗: 3 - 9 months
Computer-based behavioural task developed by the investigators to understand decision making in OCD.
次要结局
- Patient EX/RP Adherence Scale (PEAS)(3 - 9 months)
- International Cognitive Ability Resource (ICAR16)(3 - 9 months)
- The World Health Organization Quality of Life Brief Version (WHOQOL-BREF)(3 - 9 months)
- Sheehan Disability Scale (SDS)(3 - 9 months)
- Brief Experiential Avoidance Questionnaire (BEAQ)(3 - 9 months)
- State-Trait Anxiety Inventory (STAI)(3 - 9 months)
- Zung Self-Rating Depression Scale (SDS)(3 - 9 months)
- Short form of Obsessive Beliefs Questionnaire (OBQ)(3 - 9 months)
- Worry Domains Questionnaire - Short Form (WDQ-SF)(3 - 9 months)
- Anxiety Sensitivity Index (ASI-3)(3 - 9 months)