Cognitive and Neural Networks in Psychiatry (CNNP): Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure (ERP in Silico)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obsessive-Compulsive Disorder
- Sponsor
- University College, London
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Yale-Brown obsessive compulsive scale (Y-BOCS)
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The aim of this study is to understand why patients with obsessive-compulsive disorder (OCD) fail in therapy.
To understand the neural mechanisms involved in exposure therapy that support success and clinical improvement in order to improve therapy outcomes for OCD patients.
Detailed Description
A course of therapy is recommended for individuals with obsessive-compulsive disorder (OCD). It is usually a type of cognitive behavioural therapy (CBT) with exposure and response prevention (ERP). In this study the investigators assess patients pre-therapy and post-therapy evaluating symptom severity (measured by the Y-BOCS) and decision-making (measured by online questionnaires and computer-based behavioural tasks). To examine how decisions are formed in patients undergoing OCD CBT, how behaviour changes after a non-pharmacological therapy module and how it is associated to the alleviation of OCD symptoms. The study, which will recruit 90 patients, is based at University College London - Wellcome Centre for Human Neuroimaging. This study is a part of the Cognitive and Neural Networks in Psychiatry (CNNP) study.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of obsessive-compulsive disorder (OCD)
- •Fluent in written and spoken English
- •Normal/corrected to normal vision
- •Expecting to start OCD therapy
Exclusion Criteria
- •Autism spectrum disorder, psychosis, schizophrenia, addiction, substance abuse, bipolar, hoarding, or Tourette disorder
- •Hearing conditions: tinnitus, ear inflammation, hearing sensitivity, hearing loss, requires hearing aids
- •Colour blindness
- •Severe learning disabilities
Outcomes
Primary Outcomes
Yale-Brown obsessive compulsive scale (Y-BOCS)
Time Frame: 3 - 9 months
The Y-BOCS is a 10-item scale used to assess symptom severity in OCD.
Decision making and learning tasks
Time Frame: 3 - 9 months
Computer-based behavioural task developed by the investigators to understand decision making in OCD.
Secondary Outcomes
- Patient EX/RP Adherence Scale (PEAS)(3 - 9 months)
- International Cognitive Ability Resource (ICAR16)(3 - 9 months)
- The World Health Organization Quality of Life Brief Version (WHOQOL-BREF)(3 - 9 months)
- Sheehan Disability Scale (SDS)(3 - 9 months)
- Brief Experiential Avoidance Questionnaire (BEAQ)(3 - 9 months)
- State-Trait Anxiety Inventory (STAI)(3 - 9 months)
- Zung Self-Rating Depression Scale (SDS)(3 - 9 months)
- Short form of Obsessive Beliefs Questionnaire (OBQ)(3 - 9 months)
- Worry Domains Questionnaire - Short Form (WDQ-SF)(3 - 9 months)
- Anxiety Sensitivity Index (ASI-3)(3 - 9 months)