NCT02891655已完成不适用
KERatoconus and Metalloproteinases InvesTigation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- expression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) in epithelial cells
研究概览
简要总结
Corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of MMP at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and Galectin-3 by epithelial cells. A differential expression of EMMPRIN, Galectin-3 and metalloproteinases (MMP) may be observed between the apex of the keratoconus and the peripheral cornea. Highlighting the implication of EMMPRIN and Galectin-3 could lead to the development of specific inhibitors to slow or to stop keratoconus evolution.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18 years old
- •Patient with keratoconus undergoing corneal collagen cross-linking (epithelium-off methods)
- •Patient with keratoconus undergoing his first corneal graft for optical indication (control)
排除标准
- •Patient with keratoconus undergoing corneal graft for tectonic indication
- •Patient undergoing corneal refractive surgery (refractive photokeratectomy) with a normal topography, a normal slit lamp examination and no previous ophthalmic condition (control)
- •pregnant or breast feeding patient
- •patient under judiciary protection
- •patient opposition to participate in the study
结局指标
主要结局
expression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) in epithelial cells
时间窗: baseline
次要结局
未报告次要终点
研究者
研究点 (1)
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