Risk Factor for Readmission and Death of Lower Respiratory Infections in Older Adults

Completed

• Conditions: Lower Respiratory Infection; Death; Readmission; Anemia
• Interventions: Other: no intervention

• Registration Number: NCT05355324
• Lead Sponsor: Beijing Tongren Hospital

Brief Summary

Lower respiratory tract infection(LRTI) is a prevalent disease that threatens the health of older people worldwide. Anemia is also a common disorder in the elderly, and its prevalence increases significantly with age. Most factors that contribute to the development of anemia are improvable. Therefore, we investigated whether anemia was a risk factor for LRTI-caused readmission and death in the elderly occurring within 1 year of discharge from the hospital.

Detailed Description

Objectives: To investigate the effect of anemia on readmission and deaths in the older adults following lower respiratory tract infection (LRTI)-caused hospitalization.

Design: A retrospective cohort study. Setting and Participants: Older patients (age: ≥ 80 years) hospitalized at the Department of Geriatrics, from March 2016 to December 2019 to undergo treatment for LRTIs were included.

Methods: The patients were divided into two groups (anemia and non-anemia) based on the level of hemoglobin. They were kept under observation till the occurrence of mortality event or 1 year after discharge. The primary follow-up outcome was LRTI-caused readmission and/or death.

Study Timeline

• Study Start: 2016-03-01
• Primary Completion: 2019-12-31
• Study Completion: 2021-12-31
• Status Verified: 2022-04
• Study First Submitted: 2022-04-21
• Study First Submitted QC: 2022-04-27
• Last Update Submitted: 2022-04-27
• Study First Posted: 2022-05-02
• Last Update Posted: 2022-05-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 215

Inclusion Criteria

• Age ≥ 80 years
• lower respiratory tract infection

Exclusion Criteria

• Died at the time of first admission
• Active malignancy
• Tuberculosis
• Anemia caused by gastrointestinal bleeding of unknown origin
• Achalasia of the cardia
• Could not be followed up after discharge
• Data were missing

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
anemia	no intervention	patients with anemia
non-anemia	no intervention	patients without anemia

Primary Outcome Measures

Name	Time	Method
Number of Patients with Readmission and/ or Death Caused by Lower Respiratory Tract Infection(LRTI) within One Year of Discharge	March 2016 to 27 December 2019	Number of Patients with Readmission Caused by LRTI within One Year of Discharge. Number of Patients with Death Caused by LRTI within One Year of Discharge.