Research on the effectiveness of cognitive training using VR in patients with cognitive decline

Not Applicable

Active, not recruiting

Conditions: Mental and behavioral disorders

Registration Number: KCT0005243

Lead Sponsor: Gachon University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Active, not recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

1. Patients with mild cognitive impairment according to Petersen's criteria (Petersen et al., 1999) or mild neurocognitive disorder according to DSM-5
2. Participants with subjective cognitive decline (Jessen et al. 2014)
3. Age = 60
4. MMSE = 20
5. Individuals with no major lesion on Brain MRI such as intracranial haemorrhage, cerebral, cerebellar, or brainstem infarction, hydrocephalus, traumatic brain injury, severe white matter hyperintensity, tumours, multiple sclerosis, or vasculitis.
6. Individuals who voluntarily agreed to participate in the study

Exclusion Criteria

1. major psychiatric disorders such as major neurocognitive disorder, schizophrenia, bipolar disorder, and depressive disorder other than mild cognitive disorder and mild neurocognitive disorder
2. history of neurodegenerative disorders including Creutzfeldt-Jakob disease, Pick’s disease, Huntington’s disease, Parkinson’s disease, inflammation associated with human immunodeficiency viruses, and syphilis
3. vascular major neurocognitive disorder according to DSM-5
4. history of cerebral infarction within 1 year of the screening
5. participation of other clinical trial including pharmacotherapy within 3 months of the screening
6. participants who are not possible to undergo brain MRI or interview.
7. current major cancer including brain tumor
8. drug or medication abuser
9. Subjects deemed inappropriate by researchers to participate in the study

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MMSE;digit span test;Boston naming test;Rey-Osterrieth complex figure test, copy;Seoul verbal learnin test;Controlled oral word association test;Stroop test;Trail making test

Secondary Outcome Measures

Name	Time	Method
Geriatric depression scale;Apathy evaluation scale;Positive and negative affect schedule;Quality of life-Alzheimer's disease;Presence questionnaire;Simulator Sickness Questionnaire