Metabolomic Embryo Profiles of Obese in Vitro Fertilization (IVF) Patients and Their Relationship With Polycystic Ovary Syndrome (PCO)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Metabolic profile of culture media of Day 3 embryos
研究概览
简要总结
The present study aims to elucidate if there is a metabolomic profile alteration in the embryos of obese women in order to understand if the reduced implantation rate observed in these patients is directly related to this factor. Furthermore, the investigators seek to establish if there is any difference between obese women with Polycystic Ovary Syndrome (PCO) and without PCO. The investigators compare these metabolomic profile embryos with embryos of egg-donation programme.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI > 30 kg/m2
- •Age < 38 years old
- •Non smokers
- •First IVF cycle (groups 2 & 3, not Control group)
- •Normal uterus (seen by ultrasound)
- •normal basal hormonal profile(FSH,LH,estradiol,testosterone,androstenedione, insulin, SHBG, glucose, AMH)
- •Antral follicle count(> 5 FA for each ovary)
- •Menses every 25-35 days.
排除标准
- •< 5 or > 20 oocytes retrieved after stimulation cycle
- •estradiol >3000 pg/ml or progesterone > 1,5 ng/ml on the hCG day.
- •< 2 evolutive embryos in the culture medium.
结局指标
主要结局
Metabolic profile of culture media of Day 3 embryos
时间窗: 3 days
Determine differences in the metabolomic profile of the culture media of day 3 embryos, obtained after in vitro fertilization, according to the presence of obesity associated or not with polycystic ovary syndrome.
次要结局
未报告次要终点
研究者
Jose Bellver
Gynecologist IVI Valencia
Instituto Valenciano de Infertilidad, IVI VALENCIA