How common is lower back inflammation in patients with known inflammatory bowel disease such as Crohn’s disease and ulcerative colitis picked up on imaging for their bowel symptoms?

Not Applicable

Completed

• Conditions: Axial Spondyloarthritis / Ankylosing Spondylitis, Spondyloarthritis, Rheumatology; Musculoskeletal Diseases

• Registration Number: ISRCTN11108086
• Lead Sponsor: orfolk & Norwich University Hospital NHS Foundation Trust (NNUH) - Lead Sponsor

Brief Summary

2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36243419/ (added 25/10/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-02-26
• Study Completion: 2020-06-14
• Last Update Posted: 6 November 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

Inclusion criteria for Phase 1 (postal survey):
1. CT scan performed for non-musculoskeletal indications
2. Age between 18 and 55 years old inclusive at the time of CT scan
3. Verified IBD diagnosis (by gastroenterologist via gastroenterology clinical letter +/- supportive histology/radiology results using electronic medical, lab, radiology records)
4. Presence of incidental Computer Tomographic defined Sacroiliitis (CTSI) which is defined as the presence of sacroiliac joint ankylosis or total erosion score (TES) of =3 or > 0.5 cm iliac sclerosis or > 0.3 cm sacral sclerosis

Inclusion criteria for Phase 2 (clinical assessment):
1. Chronic back pain (> 3 months)
2. Onset of back pain before 45 years old
3. Including known/previous diagnosis of AS or axSpA (if unable to verify diagnosis retrospectively)

Exclusion Criteria

1. Unable to tolerate MRI scanning (e.g. current history of claustrophobia) or contra-indication to MRI scanning (including but not limited to e.g. pacemaker, pregnancy, metallic or conducting foreign body, etc.)
2. Age < 18 or > 55 years
3. Lacking in capacity and/or unable to give informed consent
4. Unable to understand English to sufficient degree to be able to complete a questionnaire
5. Illiteracy
6. Prisoners
7. Unwilling to take part in the study

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of Inflammatory Bowel Disease patients with incidental Computed Tomographic defined Sacroiliitis (CTSI) who have a rheumatologist-verified diagnosis of Axial Spondyloarthritis

Secondary Outcome Measures

Name	Time	Method
<br> 1. Proportion of patients who fulfil the Assessment of Spondyloarthritis International Society (ASAS) classification criteria for Axial Spondyloarthritis<br> 2. Proportion of symptomatic vs asymptomatic incidental CTSI<br>