A randomized open-labelled comparative clinical study to evaluate the efficacy of Navanga Kwath with Vitamin E in the management of Non-Alcoholic Fatty Liver Disease(Yakritroga)

Non–alcoholic fatty liver disease represents a spectrum of liver disease encompassing simple fatty infiltration, inflammation and cirrhosis, in the absence of excessive alcohol consumption. The global prevalence of NAFLD is estimated to 24%. Vitiation of agni caused by Raktadhatu Dushti and Kapha dosha leads to formation of ama rasa or apakva anna rasa. Kapha dushti causes impaired metabolism of fat resulting in the deposition of excessive fat (Medas) in the liver. Most common symptoms such as Avipaka, Agnimandya, Aruchi, Utklesha, Mandavyatha, Gaurvanvita, etc. Based on all these signs and symptoms of NAFLD patients it can be correlated with Agnivikrita, Yakritroga and Medodushti vikara. Through the proper administration of Ayurvedic treatment protocol along with life style modification progression of this disease can be prevented. Accordingly, a study will be conducted with the aim to compare the efficacy of Navanga Kwatha and Vitamin E in the management of NAFLD (Yakritroga) for which 60 patients will be randomly selected and divided into two groups. In group A (30 patients) 24 ml of Navanga Kwatha (Intervention) will be given after meal three times a day for 42 days. In group B (30 patients) 400mg Vitamin E will be given with water after meal twice a day for 42 days. Patient will be regularly followed up on 0th, 7th, 14th, 21th, 28th, 35th, 42th (during treatment) and 56th and 70th day (post treatment). Clinical features and laboratory parameters will be analyzed during and after treatment and result will be analyzed using appropriate statistical methods.