Changes in cognition through a combined memory and psychomotor training intervention in patients with Cancer Related Cognitive Impairment: a randomized controlled trial.

Not Applicable

Recruiting

• Conditions: Cancer related cognitive impairment

• Registration Number: DRKS00027361
• Lead Sponsor: niversitätsklinikum Würzburg, Comprehensive Cancer Center Mainfranken

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 170

Inclusion Criteria

curative tumor diagnosis (malignant Neoplasia)
- after chemotherapy and/or radiotherapy and/or ongoing antibody therapy
- age at least 18 years to 79 years
- subjective cognitive impairment (FACT-COG <=55)
- access to a device with internet access

Exclusion Criteria

- lack of German language skills and linguistic disorders
- severe cognitive impairment such as dementia
- brain tumors
- immobile, bedridden and unstable resilient patients
- patients with palliative therapy goals

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The change in cognition via alertness (without signal tone) is examined with the test battery of attentional performance (TAP).Reaction time in milliseconds is measured at time points T1-T3 (T1: baseline; T2: after 3 months; T3: after 6 months).

Secondary Outcome Measures

Name	Time	Method
-Cognition (objective): tests of attention performance via alertness (with signal), go/nogo, working memory; verbal learning and memory test; trail making test A and B.<br>- Cognition (PRO): FACT-Cog. <br>- Health-related quality of life (PRO): EORTC-QLQ-C30; <br>- Cancer-related fatigue (PRO): EORTC-QLQ-FA12; <br>- Depression (PRO): PHQ9; anxiety (PRO): GAD7.<br>-Physical performance: 6-minute walking test.<br>Confounders: sociodemographic data, medical data<br>All parameters (except sociodemographic data: collected only at T1) will be collected at time points T1-T3 (T1: baseline examination; T2: after 3 months; T3: after 6 months).