Safety Study of Dexmedetomidine in Septic Patients
- Registration Number
- NCT01976754
- Lead Sponsor
- First Affiliated Hospital of Zhejiang University
- Brief Summary
Septic patients in Intensive Care Unit always need mechanical ventilation and conscious-sedation. But the recommended dose 0.2-0.7μg/kg/h could not run well because of wide range. The purpose of this study is to find the effective dose of dexmedetomidine adult septic patients of mechanical ventilation .
- Detailed Description
Inclusion Criteria:
Age: between 18 years mechanical ventilation RASS≥2 A diagnosis of sepsis within 48 hours
Exclusion Criteria:
Cardiac disease Cardiac rhythm abnormalities liver dysfunction coma severe hypotension muscle relaxant users
Primary Outcome Measures:
Dose of dexmedetomidine
Secondary Outcome Measures:
RASS score Requirement for rescue intervention, RASS will be recorded per hour.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- intubated patients RASS≥2 A diagnosis of sepsis within 48h
Exclusion Criteria
- Cardiac disease Cardiac rhythm abnormalities liver dysfunction coma severe hypotension muscle relaxant users
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description dexmedetomidine,sepsis,ED50 Dexmedetomidine Intervention Name: dexmedetomidine dosage form: intravenous injection dosage：0.2-0.7μg/kg/h frequency: 1 duration:12 hours
- Primary Outcome Measures
Name Time Method Dose of dexmedetomidine 12 hours
- Secondary Outcome Measures
Name Time Method RASS score Requirement for rescue intervention, RASS will be recorded per hour. 1 hour
Trial Locations
- Locations (1)
Zhanqin Zhang
🇨🇳Hangzhou, Zhejiang, China