Predicting Prognosis in Subacute Ischemic Stroke Through Brain Perfusion and Collateral Circulation With Multimodal Imaging

The First Hospital of Hebei Medical University1 site in 1 country28 target enrollmentFebruary 1, 2021

ConditionsThe Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: The Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke
Sponsor: The First Hospital of Hebei Medical University
Enrollment: 28
Locations: 1
Primary Endpoint: Modified Rankin Scale（mRS） score after 3 months of onset
Status: Completed
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

We enrolled patients with subacute IS, associated with moderate-to-severe stenosis of the unilateral cervical internal carotid artery, who underwent 4D ASL. Perfusion levels and collateral circulation were compared between groups with favorable prognosis (modified Rankin scale [mRS] ≤ 2) and poor prognosis (mRS > 2).

Registry

clinicaltrials.gov

Start Date

February 1, 2021

End Date

December 31, 2023

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

The First Hospital of Hebei Medical University

Responsible Party

Principal Investigator

Zhiyuan Shen

The First Hospital of Hebei Medical University

Eligibility Criteria

Inclusion Criteria

•Confirmed unilateral internal carotid artery/MCA atherosclerotic stenosis/occlusion with a stenosis degree \> 50% verified through computed tomography angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA).
•Presence of IS or transient ischemic attack (TIA) symptoms in the circulating blood supply area within the preceding 48 h.
•Asymptomatic patients with no history of IS or TIA in the past 6 months.
•Performance of 4D ASL tests during hospitalization.

Exclusion Criteria

•Moderate-to-severe stenosis/occlusion of the contralateral internal carotid artery/middle cerebral arteries.
•Age ≤ 18 years old.
•Cardioembolic cerebral infarction.
•Moyamoya disease.
•Combined or previous cerebral hemorrhage or subarachnoid hemorrhage
•History of previous cerebral infarction.
•Claustrophobia or the presence of intracranial metal implants, cochlear implants, or pacemakers.

Outcomes

Primary Outcomes

Modified Rankin Scale（mRS） score after 3 months of onset

Time Frame: 3 months

mRS scores range from 0 to 6, where 0 indicates no symptoms, 3 indicates moderate disability, 4 indicates moderately severe disability, 5 indicates severe disability, and 6 indicates death. Patients were categorized into a good prognosis group (mRS ≤ 2) and a poor prognosis group (mRS \> 2).