Evaluation of physical capacity by handgrip in order to examine the physical capacity, prognosis and response to therapy of patients with pulmonary hypertensio

• Conditions: I27.0; I27.2; Primary pulmonary hypertension; Other secondary pulmonary hypertension

• Registration Number: DRKS00022333
• Lead Sponsor: niversitätsklinikum Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 154

Inclusion Criteria

patients with pulmonary hypertension
- signed written informed consent
- age 18 and older
- healthy subjects without known heart disease

Exclusion Criteria

- no handgrip manouever possible
- echochardiographic parameters not complying with the inclusion criteria
- life expectancy less than twelve months due to a known disease
- patients with authorized representatives

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
This is a hypothesis generating study. The primary endpoint is the increase in physical capacity in patients who show a contractile reserve under handgrip, measured by the six minute walking test. The null hypothesis (H0) is: no increase in physical capacity in patients who have a contractile reserve under handgrip. The alternative hypothesis (H1): increase in physical capacity in patients that show a contractile reserve under handgrip.

Secondary Outcome Measures

Name	Time	Method
Secondary endpoint is the association of the physical capacity with echo parameters (e.g. PAPsys, TAPSE, S', FAC, RV strain) and the association with mortality and morbidity.