How may exercise reduce fatigue in patients with cancer. A pilot study examining the role of muscular, immune and endocrine systems.

Phase 3

Completed

Conditions: breast cancer
colorectal cancer
10017991

Registration Number: NL-OMON43997

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Patients with histological confirmed primary colorectal cancer or breast cancer stage II/III aged * 18 years, who will be treated with (neo-)adjuvant or first line chemotherapy.

Exclusion Criteria

Patients who are not able to perform basic activities such as walking or biking, who show cognitive disorders or severe emotional instability, who are suffering from other disabling co-morbidity that might hamper physical exercise (e.g. heart failure, chronic obstructive pulmonary disease (COPD), orthopaedic conditions and neurological disorders), and patients who are unable to understand and read the Dutch language will be excluded from the study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main outcome of measures of this pilot study are:<br /><br>a) Measurements of muscles contractile properties, i.e. muscle force, speed of<br /><br>force development and relaxation, and fatigability.<br /><br>b) Measures of inflammation (CRP, IL-6, TNF-alpha)<br /><br>c) Measures of the insulin pathway (insulin, IGF, C-peptide).</p><br>

Secondary Outcome Measures