A Single Center, Open-label, Randomized Comparative Study to Evaluate the Effect of Aliskiren on Myocardial Perfusion Reserve and Coronary Flow Reserve in Hypertensive Patients with a history of Myocardial Infarction - An Exploratory Study to Evaluate the Improvement of Myocardial Perfusion Reserve and Coronary Flow Reserve by Aliskiren Treatment in Patients with Prior Myocardial Infarction

The University of Tokyo, department of cardiovascular medicine0 个研究点目标入组 40 人开始时间: 2011年5月1日最近更新: 2023年10月17日

适应症

试验速览

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•1.Intolerance, anaphylaxis, or any history of hypersensitivity to aliskiren 2.Treated with high dose of RAS blockade 3.Initiation or change-a-dose/discontinuation of statin during 3 months prior to the registration, or planned change in a dose of statin during participating to this study 4.History of coronary artery bypass graft surgery 5.With any contraindication for MRI a)Pacemaker or ICD b)Implanted inner ear device c)Artificial tooth (regarded as an aberration if provided, however, that physician decided it doesn't matter) d)patient undergoing bronchial asthma treatment e)History of artificial vessel replacement for aortic aneurysm f)History of surgical clip therapy for brain aneurysm g)eGFR<50mL/min/1.73 m2 during 1 month prior to the MRI examination h)Judged as "Imcompetent for the study" by investigators i)Intolerance, anaphylaxis, or any history of hypersensitivity to Gd-DTPA 6.Uncontrolled severe diabetes ( HbA1c>9) 7.Unstable angina or a history of acute MI or stroke during 3 months prior to the registration 8.LVEF <30% 9.Severe liver dysfunction 10.Severe kidney disease 11.Pregnant, Women of Child Bearing Potential or using effective methods of contraception as defined by local Health Authority 12.Nursing (lactating) women 13.Hyperkalemia ( plasma K >5.5mEq/l) 14.eGFR<50mL/min/1.73 m2 during 1 month prior to the registration 15.Judged as "Imcompetent for the study" by investigators

发起方

The University of Tokyo, department of cardiovascular medicine