Treatment of sleep disorders in patients with non-psychotic depressed

Phase 2

• Conditions: Depressive disorder.; Mood [affective] disorders; F30, F31,

• Registration Number: IRCT2012100411004N1
• Lead Sponsor: Vice chancellor for research, Hamadan university of medical sciences

Brief Summary

Sleep disturbances are nearly universal in psychiatric disorders, especially mood disorders. Research investigating associations between sleep and affective illness has largely focused on depression. This study evaluated the efficacy of lorazepam and Sleep hygiene education, alone or in combination on sleep in patients with non-psychotic depression. One hundred twenty patients with non-psychotic depression were randomly divided into 3 groups and either received Sleep hygiene education (n = 40), lorazepam (n = 40) and combined (n = 40) who were admitted to Farshchian hospital in Hamadan, Iran. The intervention lasted for 8 weeks. Pittsburgh Sleep Quality Index (PSQI) was used to measure of overall sleep quality. ANCOVA including and MANOVA were used to test intra-group and inter-group differences. Result showed that Sleep hygiene education, lorazepam and combined intervention were significant effect on sleep in patients with non-psychotic depression. There was no significant difference between Sleep hygiene educations and lorazepam. But found that intervention with a combination of Sleep hygiene educations and lorazepam had significant advantages over intervention with lorazepam or Sleep hygiene education alone (P

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Middle age group (35-60? No history of psychiatric disorders associated? No history of serious physical illness? Treated with SSRI antidepressants? The ability to read and write. Exclusion criteria included Electroconvulsive therapy? Having physical pain from chronic diseases? History of substance abuse.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sleep disorders. Timepoint: Before and 4 week after. Method of measurement: Sleep Disorders Inventory.

Secondary Outcome Measures

Name	Time	Method
Depressive level. Timepoint: Before and four weeks after. Method of measurement: Hamilton Depression Scale.