Quantification of Myocardial Fibrosis in Aortis Stenosis

Not yet recruiting

• Conditions: Aortic Valve Stenosis; Myocardial Fibrosis

• Registration Number: NCT06571175
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-7-10
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Part of the initial cohort that were included in the baseline study<br><br> - Still able to undergo protocolled investigations<br><br> - Patients: Mild, moderate or severe AS<br><br>Exclusion Criteria:<br><br> - Renal insufficiency<br><br> - Previously myocardial infarction (ECG, echocardiogram or hospital record)<br><br> - Severe valvular heart disease (except patients)<br><br> - Other cardiac disease known to cause myocardial fibrosis<br><br> - Severe hypertension<br><br> - Other medical conditions deterring protocolled investigation and follow-up<br><br> - Other medical conditions affecting 5-years prognosis (cancer, pulmonary disease)<br><br> - Severely reduced image-quality (echocardiography and MRI)

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiovascular morbidity;Cardiovascular mortality

Secondary Outcome Measures

Name	Time	Method
All cause mortality;Time of first re-hospitalization;Cardiac systolic function;Cardiac diastolic function (1 of 5);Cardiac diastolic function (2 of 5);Cardiac diastolic function (3 of 5);Cardiac diastolic function (4 of 5);Cardiac diastolic function (5 of 5);Velocity of natural mechanical waves propagating through the myocardium