Heterogeneity of Metastatic Neuroendocrine Tumors as Determined With 18F-dihydroxyphenylalanine-PET /CT, a Retrospective Analysis

Completed

• Conditions: Neuroendocrine Tumors
• Interventions: Other: Metastasized intestinal NET

• Registration Number: NCT02646644
• Lead Sponsor: University Medical Center Groningen

Brief Summary

In an individual cancer patient extensive genetic and phenotypic variation exists between and within tumor lesions. Tumour load in NET patients can be measured with fluorine-18-L-dihydroxyphenylalaninepositron emission tomography (18F-DOPA-PET) scan.

This aim of the study is to investigate heterogeneity between tumor lesions within patients with intestinal NET by determining the differences in tracer uptake measured on a 18F- DOPA-PET scan retrospectively.

Detailed Description

In an individual cancer patient extensive genetic and phenotypic variation exists between and within tumor lesions. Tumour load in NET patients can be measured with fluorine-18-L-dihydroxyphenylalanine positron emission tomography (18F-DOPA-PET) scan.

This aim of the study is to investigate heterogeneity between tumor lesions within patients with intestinal NET by determining the differences in tracer uptake measured on a 18F- DOPA-PET scan in retrospect.

Study Timeline

• Study First Submitted: 2015-12-24
• Study Start: 2016-01
• Study First Submitted QC: 2016-01-02
• Study First Posted: 2016-01-06
• Primary Completion: 2017-05
• Study Completion: 2017-05
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-03
• Last Update Posted: 2024-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• age ≥18 years
• diagnosis of intestinal NET diagnosed by a dedicated NET specialist
• more than one positive lesion on the 18F-DOPA-PET scan.
• available CT-scan within 6 months before or after the 18F-DOPA-PET-scan.

Exclusion Criteria

• no clinical data available at the UMCG, besides the results of the DOPA PET scan.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Metastasized intestinal NET	Metastasized intestinal NET	We will select the 18F- DOPA-PET scans conducted in the Universtiy Medical Center of Groningen (UMCG) of adult patients with a metastasized intestinal NET between February 2014 until November 2015. Only patients of whose clinical data are available within the UMCG are included.

Primary Outcome Measures

Name	Time	Method
tracer uptake in tumor lesions within patients with intestinal NET	at the day of scan	The difference in tracer uptake of tumor lesions within patients with intestinal NET measured on a 18F- DOPA-PET scan.

Secondary Outcome Measures

Name	Time	Method
tracer uptake in tumor lesions within patients with intestinal NET adjusted for uptake of background organ	at the day of scan	The difference in tracer uptake of tumor lesions adjusted for uptake of background organ within patients with intestinal NET measured on a 18F- DOPA-PET scan.

Trial Locations

Locations (1)

University Medical Center Groningen; 🇳🇱 Groningen, Netherlands