Atrophic Gastritis Predicts the Risk of Gastric Cancer

Recruiting

• Conditions: Atrophic Gastritis
• Interventions: Other: Esophagogastroscopy (OLGA 0-Ⅰ); Other: Esophagogastroscopy (OLGA II); Other: Esophagogastroscopy (OLGA III-IV)

• Registration Number: NCT06203327
• Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Brief Summary

Despite declining incidence rates, gastric cancer (GC) ranks the fourth leading cause of cancer-related mortality and the fifth most common cancer worldwide, with the highest incidence reported in Eastern Asia. The 5-year overall survival rate of early GC exceeds 90%, which was well above advanced GC. Most intestinal-type GCs follow the Correa cascade-inflammation,atrophy, intestinal metaplasia (IM), dysplasia and subsequent carcinoma. The presence of gastric mucosal atrophy and intestinal metaplasia are important risk factors for GC. The purpose of this study was to investigate the incidence of GC attributed to atrophic gastritis in a region with high incidence of GC.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-12
• Study Start: 2023-12-15
• Study First Submitted: 2023-12-25
• Study First Submitted QC: 2024-01-11
• Study First Posted: 2024-01-12
• Last Update Submitted: 2024-12-26
• Last Update Posted: 2024-12-30
• Primary Completion: 2034-12-31
• Study Completion: 2034-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2042

Inclusion Criteria

• Ability and willingness to participate in the study and to sign and give informed consent
• Biopsies were collected based on the recommendation of updated Sydney system

Exclusion Criteria

• under 18 or over 80 years old
• history of gastrectomy
• severe systemic diseases or malignancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
OLGA 0-I	Esophagogastroscopy (OLGA 0-Ⅰ)	-
OLGA II	Esophagogastroscopy (OLGA II)	-
OLGA III-IV	Esophagogastroscopy (OLGA III-IV)	-

Primary Outcome Measures

Name	Time	Method
early gastric neoplasm	After the baseline endoscopy, participants were scheduled for surveillance endoscopies at years 3-5 for subjects with operative link on gastritis assessment (OLGA) 0-Ⅰ, at years 2-3 for subjects with OLGA II and 1 year for subjects with OLGA III-IV.	histological diagnosis of high-grade dysplasia, and adenocarcinoma.

Trial Locations

Locations (1)

Renji Hospital, School of Medicine, Shanghai Jiao Tong University; 🇨🇳 Shanghai, Shanghai, China