The use of dynamic X-rays for patients with respiratory disease

Not Applicable

Completed

• Conditions: Asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and post-COVID-19 infection; Respiratory

• Registration Number: ISRCTN14507847
• Lead Sponsor: Royal Liverpool University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-11-01
• Study Start: 2023-12-13
• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

1. Undergoing PFTs in the next 6 months for clinical reasons
2. Asthma group:
2.1. A clinical history in keeping with asthma
2.2. Physiological evidence of asthma (defined as post bronchodilator reversibility, variable FEV1
over time or a previous positive bronchial challenge test)
3. COPD group:
3.1. A clinical history in keeping with COPD
3.2. Physiological evidence of COPD (FEV1/FVC ratio of <0.7)
4. ILD group:
4.1. A clinical history in keeping with ILD
4.2. HRCT findings in keeping with ILD
5. Post-COVID-19 group:
5.1. Serologically confirmed COVID-19 infection
5.2. Chest X-ray or CT findings in keeping with COVID-19
5.3. At least 12 weeks post-recovery from acute COVID-19
6. Fluent spoken English - to ensure a comprehensive understanding of the research project and their proposed involvement
7. Able to achieve positioning for a PA and lateral chest X-ray for a 30-second period

Exclusion Criteria

1. Unable to provide informed consent
2. Significant other respiratory co-morbidities as judged by study doctor
3. Recent/ongoing exacerbation of airways disease or interstitial lung disease within the last 4 weeks (from the recruitment date).
4. Women of child bearing age; a positive pregnancy test or refusal of pregnancy test (a negative pregnancy test on the day of DCR is a requirement).
5. Significant research-related radiation exposure in the last 12 months prior to consent (from participation in previous studies involving radiation exposure, with a research dose constraint of 0.4 mSv).

Study & Design

• Study Type: Observational
• Study Design: Not specified