A Randomised Controlled Trial of Online Transcranial Direct Current Stimulation (tDCS) in Enhancing the Effects of Cognitive Training in patients with Schizophrenia
试验速览
- 阶段
- Unknown
- 状态
- 招募中
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- CANTAB
研究概览
简要总结
The primary objective of the study is to investigate the adjunct effect of online tDCS with cognitive training on specific cognitive domains in stable schizophrenia patients. (i) right after the intervention (ii) whether maintenance effect at 1 month after intervention. The secondary objective of the study is to probe (i) any effects on affective , psychotic and negative symptoms; (ii) psychosocial functioning, subjective quality of life (QOL); (iii) the motivation and enjoyment of continuing playing the computerized cognitive training; (iv) the tolerability and adverse events of tDCS among patients with schizophrenia.
研究设计
- 研究类型
- Interventional
- 主要目的
- 随机平行对照
- 盲法
- Double
入排标准
- 年龄范围
- 18 至 65（—）
- 性别
- All
入选标准
- •Patients receiving rehabilitation service in Tai Po Hospital aged between 18-65 years old;
- •diagnosis of schizophrenia meeting the diagnostic criteria of the World Health Organizations 10thversion of the International Statistical Classification of Disease and Related Health Problems (ICD-10),it will be made clinically by the study psychiatrist based on ICD-10;
- •right-handedness;
- •able to understand spoken instructions in Cantonese and able to read traditional Chinese.
排除标准
- •History of significant head trauma;
- •active abuse of alcohol or illegal substances;
- •significant neurologic history such as dementia, stroke, seizure, Parkinsons disease, multiple sclerosis;
- •concurrent use of cognitive-enhancing medications e.g. acetylcholinesterase inhibitors ;
- •documented history of learning disability;
- •f. implanted with pacemakers, intracranial electrodes, defibrillators;
- •g. changes in medication regime over the 2 weeks before or during the study period.
研究组 & 干预措施
Concurrent Training Group
Concurrent Computerised Cognitive Training with active tDCS stimulation
Control group
Computerised Cognitive Training with sham tDCS stimulation
结局指标
主要结局
CANTAB
次要结局
未报告次要终点