Sorafenib in combination with local micro-therapy in patients with inoperable liver cancer

Recruitment & Eligibility

Status: ot Recruiting

Sex: Not specified

Target Recruitment: 665

Inclusion Criteria

1. Age: 18-85 years 2. Diagnosis of hepatocellular carcinoma 3. If extrahepatic metastases: liver-dominant disease 4. Stage BCLC A, B, or C 5. Child-Pugh A, Child-Pugh B up to 7 points (in patients receiving anticoagulant therapy: Child-Pugh score up to 5 points; INR category not regarded for calculation of the Child-Pugh score) 6. Willing to comply with all study procedures 7. Has voluntarily given written informed consent
Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 222
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 443

Exclusion Criteria

1. If female, pregnant or breast feeding (females of child-bearing potential must use adequate contraception and must have a negative pregnancy test performed within 7 days prior to inclusion into this study) 2. If male, not using adequate birth control measures 3. One or more of the following: - Hemoglobin <10g/dL, - WBC <2,500 cells/mm3, - ANC <1,500 cells/mm3, - platelets <50,000/mm3, - ECOG performance status >2 4. Life expectancy <16 weeks 5. Extrahepatic metastases (except metastases to bone, lymph nodes, and adrenal glands which do not constitute an exclusion criterion) 6. Patients with known GFR <30 mL/min/1.73m2 7. PT-INR/PTT >1.5 times the upper limit of normal (patients on anticoagulation therapy will be allowed to participate provided that no prior evidence exists of an underlying abnormality in anticoagulation) 8. uncontrolled infections at the time of microtherapy 9. Child-Pugh score >7 points; in patients receiving anticoagulant therapy: Child-Pugh score >5 points (INR category not regarded for calculation of the Child-Pugh score) 10. Uncontrolled ascites 11. tumor load of the whole liver >70% 12. Contraindications for study medications according to product labeling or procedures (sorafenib, Primovist, x-ray contrast agents, SIR-Spheres, RFA, MRI, CT) incl. any contraindication to the trans-arterial interventional procedure (e.g., allergy against x-ray contrast agents, uncontrolled hyperthyroidism) 13. Prior resection of the papilla of Vater (e.g., Whipple procedure) or bile duct stent across the papilla 14. Significant cardiovascular disease; e.g., myocardial infarction within 6 months of inclusion, chronic heart failure (New York Heart Association class III or IV), unstable coronary artery disease 15. Uncontrolled hypertension 16. Thrombotic or embolic events including transient ischemic attacks within the past 6 months (tumor-related portal vein thrombosis allowed in the palliative part of the trial). 17. History of GI bleeding within 30 days before inclusion into this study 18. History of esophageal varices bleeding which has not been controlled by effective therapy and/or therapy to prevent bleeding recurrence 19. Previous malignancy other than carcinoma in situ of the skin or the cervix uteri within 5 years prior to inclusion 20. History of organ transplant (including prior liver transplantation) 21. HIV, congenital immune defect, any immunosuppressive therapy for autoimmune disease (rheumatoid arthritis) or inflammatory bowel disease 22. Mental conditions rendering the subject incapable to understand the nature, scope, and consequences of the trial 23. Close affiliation with the investigational site; e.g. first-degree relative of the investigator. 24. Participating in another therapeutic clinical trial or has completed study participation in another therapeutic clinical trial within 30 days of enrolment into this trial 25. Having been previously enrolled in this clinical trial

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method

Secondary Outcome Measures

Name	Time	Method