NL-OMON46941招募中2 期
The effects of Vitamin K2 supplementation on the progression of Coronary Artery Calcification - VitaK-CAC
Interne Geneeskunde0 个研究点目标入组 180 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 180
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- age 18 years or older
- •- Baseline Coronary Computed Tomographic Angiography (CCTA) of sufficient quality
- •- Baseline Agatston calciumscore 50 - 400
排除标准
- •- Baseline-scan of insufficient quality (due to the presence of motion artefacts, breathing artefacts or high noise-levels)
- •- Heart rate greater than 70 beats per minute during first scan.(despite adequeate treatment with metoprolol)
- •- Chronic or paroxysmal Atrial Fibrillation
- •- Presence or scheduled coronary revascularization procedure (balloon-dilatation or stent-placement in more than one artery or bypass-grafting).
- •- History of myocardial infarction or stroke within the last 6 months before CT-scan.
- •- Presence of Diabetes Mellitus type 1
- •- Known kidney disease or a Glomerular Filtration Rate (GFR) < 60 ml/min/1.73m2 calculated by the MDRD-formula (Levene; 2001).
- •- Malignant disease (exception: treated basal-cell or squamous cell carcinoma).
- •- Use of Vitamin K antagonists.
- •- A life-expectancy < 2 years
- •- Pregnancy or wish to become pregnant in the near future.
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