Diaphragm Thickness by Ultrasonography in Neurological Disorders

Not Applicable

Completed

• Conditions: Guillain-Barre Syndrome; Myasthenia Gravis
• Interventions: Radiation: diaphragmatic ultrasound

• Registration Number: NCT05324176
• Lead Sponsor: Mansoura University

Brief Summary

participants will be allocated into three groups, acute neuropathy (Guillain Barre Syndrome) group, neuromuscular junction disorder(myasthenia gravis ) group, and control group(people with neurological disorders not affecting the respiratory system.Ultrasonography is done on the diaphragm. The index test (ultrasound imaging of the diaphragm) is used. A high-resolution portable ultrasound machine is used, with a 7- to 13-MHz linear array transducer. Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration. objectives: primary outcome: to compare diaphragm thickness between the three examined groups. Secondary outcome: correlation between clinical scores and reference US values of diaphragm

Detailed Description

after IRB (institutional research board ) approval, of the faculty of medicine, Mansoura University, Egypt, written informed consent from all participants will be taken. participants will be allocated into three groups, acute neuropathy (Guillain Barre Syndrome) group, neuromuscular junction disorder(myasthenia gravis ) group, and control group(people with neurological disorders not affecting the respiratory system. inclusion group: age more than 18, both sexes. exclusion criteria: cardiopulmonary disease, chest trauma, diaphragmatic injury, body mass index more than 30. Any participant who shows respiratory dysfunction on doing arterial blood gases and pulmonary function tests will not be enrolled in the study. methods: Ultrasonography is done on the diaphragm. The index test (ultrasound imaging of the diaphragm) is used. A high-resolution portable ultrasound machine is used, with a 7- to 13-MHz linear array transducer. Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration. objectives: primary outcome: to compare diaphragm thickness between the three examined groups. Secondary outcome: correlation between clinical scores and reference US values of diaphragm

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2022-04-04
• Study First Submitted QC: 2022-04-04
• Study First Posted: 2022-04-12
• Study Start: 2022-04-13
• Status Verified: 2022-05
• Primary Completion: 2022-05-09
• Study Completion: 2022-05-13
• Last Update Submitted: 2022-05-13
• Last Update Posted: 2022-05-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• all adult patients admitted to the neurology department

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Exclusion Criteria

• cardiopulmonary diseases
• chest trauma
• diaphragmatic diseases
• Body Mass Index (BMI) > 30

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control	diaphragmatic ultrasound	Patients hospitalized with neurological disorders without affection of the respiratory system.
Gillian-Barre	diaphragmatic ultrasound	Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration.
Myasthenia Gravis	diaphragmatic ultrasound	Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration.

Primary Outcome Measures

Name	Time	Method
diaphragm thickness	within 24 hours from hospital admission	will be reported in (mm)

Secondary Outcome Measures

Name	Time	Method
Hughes clinical score	within 24 hours from hospital admission	score of disability 1-5, "Hughes RA, Newsom-Davis JM, Perkin GD, Pierce JM.Controlled trial prednisolone in acute polyneuropathy.Lancet. 1978;2:750-3"

Trial Locations

Locations (1)

Mansoura University Hospitals; 🇪🇬 Mansoura, Not In US Or Canada, Egypt