Correlation Between Epistaxis and Cardiovascular Disease

• Conditions: Cardiovascular Disease; Epistaxis
• Interventions: Biological: Blood-pressure variability

• Registration Number: NCT02677467
• Lead Sponsor: Hanyang University

Brief Summary

Investigators examine blood-pressure variance, several cardiovascular risk factors of patient with epistaxis. As a result of collected data, investigators look into correlation between epistaxis and hypertensive cardiovascular disorder.

Detailed Description

This study is prospective observational single blinded study.

A participant is visit in the ER who patient with epistaxis.

Investigators will enroll 50 patients with epistaxis. Exclusion criteria is that patient needs immediately treatment for hypertensive urgency or patient with nasal trauma.

Investigators examine blood-pressure (BP) at five times in Emergency Department (ED) and out-patient department (opd) of Otorhinolaryngology (OL) . Investigators explain this study and ask to write consent for participant. After proper management of epistaxis, investigators get blood sampling of the participant and, the participant has a reservation to "opd of cardiovascular division of Internal Medicine" (CV opd) in the hospital.

When the participant visit CV opd, the participant undergo 24-hours-BP-monitoring and Pulse wave velocity (PWV).

After that, the participant will be follow-up for 3 months.

Investigators collect 50 data from 50 participants as a registry and analyze the data.

Study Timeline

• Study First Submitted: 2016-01-31
• Status Verified: 2016-02
• Study First Submitted QC: 2016-02-08
• Last Update Submitted: 2016-02-08
• Study First Posted: 2016-02-09
• Last Update Posted: 2016-02-09
• Study Start: 2016-03
• Primary Completion: 2016-06
• Study Completion: 2016-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• age is over 18 with spontaneous epistaxis

Exclusion Criteria

• they needs immediately treatment for hypertensive urgency.
• they don't want to participate in this investigation.

Group B

Inclusion Criteria:

• age is over 18 with bleeding of wound

Exclusion Criteria:

• their wounds' condition is serious or their pain is much severe.
• they don't want to participate in this investigation.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Bleeding of wound	Blood-pressure variability	A participant enroll if their age is over 18 with bleeding of wound and their cause of visiting ER is to bleed on wound. Exclusion criteria is that their wounds' condition is serious or their pain is much severe. And, they don't want to participate in this investigation. Investigators examine their blood-pressure variability and cardiovascular risk throughout their blood sample analysis.
Spontaneous epistaxis	Blood-pressure variability	A participant enroll if their age is over 18 with spontaneous epistaxis and their cause of visiting ER is spontaneous epistaxis. Exclusion criteria is that they needs immediately treatment for hypertensive urgency. And, they don't want to participate in this investigation. Investigators examine their blood-pressure variability and cardiovascular risk throughout their blood sample analysis.

Primary Outcome Measures

Name	Time	Method
Pulse wave velocity in each group	1 day
BP variability level in each group	1 day
Cholesterol level in each group	1 day

Secondary Outcome Measures

Name	Time	Method
Smoking History in each group	1 day	Example = "12 pack-year"
Body Mass Index in each group	1 day

Trial Locations

Locations (1)

Hanyang University Guri Hospital; 🇰🇷 Guri-si, Gyeonggi-do, Korea, Republic of