Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes
- Registration Number
- NCT04707469
- Lead Sponsor
- Novo Nordisk A/S
- Brief Summary
This study compares three doses of once daily semaglutide tablets in people with type 2 diabetes who were previously treated with other oral anti-diabetic medicines. Participants will be initiated on the lowest starting dose of 3 mg and gradually increased until they reach the final trial dose of 14 mg, 25 mg or 50 mg once daily semaglutide tablets. The final three doses will be randomized (i.e., decided by chance). Participants will be administered one tablet per day for 68 weeks. Women cannot take part if they are pregnant, breast-feeding or planning to become pregnant during the study period. Women who can get pregnant will be checked for pregnancy via urine tests. Once daily semaglutide tablets (3 mg, 7 mg and 14 mg) are approved for the treatment of type 2 diabetes in the US, in the EU and in some other countries, under the brand name Rybelsus®.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1606
-
Male or female, age above or equal to 18 years at the time of signing informed consent.
-
Diagnosed with type 2 diabetes mellitus at least 180 days prior to the day of screening.
-
HbA1c of 8.0-10.5% (64-91 mmol/mol) (both inclusive).
-
BMI equal to or above 25 kg/m^2
-
Stable daily dose(s) for 90 days prior to the day of screening of any of the following treatment regimens:
-
No more than 3 of the following oral anti-diabetic drugs and at least 1 marked with a *:
- Metformin (equal to or above1500 mg or maximum tolerated or effective dose).
- Sulfonylureas (SU) (equal to or above half of the maximum approved dose according to local label or maximum tolerated or effective dose).
- Sodium/glucose cotransporter 2 (SGLT2) inhibitors (maximum tolerated dose).
-
Dipeptidyl peptidase-4 (DPP-4) inhibitors (maximally indicated dose as per local label).
-
Subjects, on treatment with stable dose of DPP-4 inhibitors at inclusion, must be willing to discontinue DPP-4 inhibitor treatment at randomisation (with no wash-out).
- Treatment with any medication indicated for the treatment of diabetes or obesity other than stated in the inclusion criteria within the past 90 days prior to the day of screening. However, short term insulin treatment for a maximum of 14 days prior to the day of screening is allowed.
- Renal impairment measured as estimated glomerular filtration rate (eGFR) value of below 30 mL/min/1.73 m^2 according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation as defined by kidney disease improving global outcomes (KDIGO 2012) classification.
- Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days prior to screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Oral semaglutide 25 mg Oral semaglutide Participants will receive once daily semaglutide tablets in a dose escalating manner for 68 weeks: 3 mg (week 1-4), 7 mg (week 5-8), 14 mg (week 9-12) and 25 mg (week 13-68). Oral semaglutide 50 mg Oral semaglutide Participants will receive once daily semaglutide tablets in a dose escalating manner for 68 weeks: 3 mg (week 1-4), 7 mg (week 5-8), 14 mg (week 9-12), 25 mg (week 13-16) and 50 mg (week 17-68). Oral semaglutide 14 mg Oral semaglutide Participants will receive once daily semaglutide tablets in a dose escalating manner for 68 weeks: 3 mg (week 1-4), 7 mg (week 5-8) and 14 mg (week 9-68).
- Primary Outcome Measures
Name Time Method Change From Baseline in Glycated Haemoglobin (HbA1c) (Week 52) Baseline (week 0), week 52 Change from baseline (week 0) in glycosylated haemoglobin (HbA1c) was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment. Percentage point refers to arithmetic difference between two percentages.
- Secondary Outcome Measures
Name Time Method Change From Baseline in Body Weight (Week 52) Baseline (week 0), week 52 Change from baseline (week 0) in body weight was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Time to Event Analyses of Rescue Medication Baseline (week 0), week 68 Time to event analyses of rescue medication was evaluated from baseline (week 0) to week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in HbA1c (Week 68) Baseline (week 0), week 68 Change from baseline (week 0) in HbA1c was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment. Percentage point refers to arithmetic difference between two percentages.
Change From Week 12 in HbA1c (Week 52) Week 12, Week 52 Change in HbA1c was evaluated from week 12 to week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment. Percentage point refers to arithmetic difference between two percentages.
Percentage of Participants Who Achieved HbA1c < 7.0 % (Week 68) At week 68 Percentage of participants who achieved HbA1c \<7.0 % at week 68 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in Waist Circumference (Week 68) Baseline (week 0), week 68 Change from baseline (week 0) in waist circumference was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in Fasting Plasma Glucose (FPG) (Week 52) Baseline (week 0), week 52 Change from baseline (week 0) in fasting plasma glucose (FPG) was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in FPG (Week 68) Baseline (week 0), week 68 Change from baseline (week 0) in FPG was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage of Participants Who Achieved HbA1c Less Than (<) 7.0 (Percent [%]) (Week 52) At week 52 Percentage of participants who achieved HbA1c \<7.0 % at week 52 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage of Participants Who Achieved HbA1c Less Than or Equal to (<=) 6.5 % (Week 52) At week 52 Percentage of participants who achieved HbA1c \<=6.5 % at week 52 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage of Participants Who Achieved HbA1c <= 6.5 % (Week 68) At week 68 Percentage of participants who achieved HbA1c \<=6.5 % at week 68 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage Change From Baseline in Body Weight (Week 52) Baseline (week 0), week 52 Percentage change from baseline (week 0) in body weight was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage Change From Week 12 in Body Weight (Week 52) Week 12, Week 52 Percentage change in body weight was evaluated from week 12 to week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in BMI (Week 68) Baseline (week 0), week 68 Change from baseline (week 0) in BMI was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in Waist Circumference (Week 52) Baseline (week 0), week 52 Change from baseline (week 0) in waist circumference was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage of Participants Who Achieved Weight Loss >= 5 % (Week 68) At week 68 Percentage of participants who achieved weight loss \>= 5 % at week 68 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in Body Weight (Week 68) Baseline (week 0), week 68 Change from baseline (week 0) in body weight was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage Change From Baseline in Body Weight (Week 68) Baseline (week 0), week 68 Percentage change from baseline (week 0) in body weight was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in Body Mass Index (BMI) (Week 52) Baseline (week 0), week 52 Change from baseline (week 0) in body mass index (BMI) was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage of Participants Who Achieved Weight Loss >= 10 % (Week 68) At week 68 Percentage of participants who achieved weight loss \>= 10 % at week 68 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in High Density Lipoproteins (HDL) (Week 52) Baseline, Week 52 Change from baseline (week 0) in HDL was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage of Participants Who Achieved Weight Loss Greater Than or Equal to (>=) 5 % (Week 52) At week 52 Percentage of participants who achieved weight loss \>= 5 % at week 52 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Percentage of Participants Who Achieved Weight Loss >= 10 % (Week 52) At week 52 Percentage of participants who achieved weight loss \>= 10 % at week 52 are presented. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in Triglycerides (Week 68) Baseline, Week 68 Change from baseline (week 0) in triglycerides was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Number of Clinically Significant Hypoglycaemic Episodes (Level 2) (<3.0 mmol/L (54 Milligram Per Decilitre [mg/dL]) or Severe Hypoglycaemic Episodes (Level 3) From baseline (week 0) up to week 68 Hypoglycaemic episodes were classified according to the American Diabetes Association 2018/ International Hypoglycaemia Study Group 2017, where glycemic criteria for level 2 was \< 3.0 mmol/L (54 mg/dL) and level 3 had no specific glucose threshold. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
Change From Baseline in Systolic Blood Pressure (Week 52) Baseline (week 0), week 52 Change from baseline (week 0) in systolic blood pressure at week 52 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
Change From Baseline in Systolic Blood Pressure (Week 68) Baseline (week 0), week 68 Change from baseline (week 0) in systolic blood pressure at week 68 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
Change From Baseline in Total Cholesterol (Week 52) Baseline, Week 52 Change from baseline (week 0) in total cholesterol was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in Total Cholesterol (Week 68) Baseline, Week 68 Change from baseline (week 0) in total cholesterol was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in Low Density Lipoproteins (LDL) (Week 52) Baseline, Week 52 Change from baseline (week 0) in LDL was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in LDL (Week 68) Baseline, Week 68 Change from baseline (week 0) in LDL was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in Triglycerides (Week 52) Baseline, Week 52 Change from baseline (week 0) in triglycerides was evaluated at week 52. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Change From Baseline in HDL (Week 68) Baseline, Week 68 Change from baseline (week 0) in HDL was evaluated at week 68. Results are based on the data from the in-trial observation period, which was the time period from when a participant was randomised until the final scheduled visit, including any period after initiation of additional anti-diabetic medication or discontinuation of trial treatment.
Number of Adverse Events From baseline (week 0) up to week 73 An adverse event (AE) defined as any unfavourable and unintended sign, including an abnormal laboratory finding, symptom or disease (new or exacerbated) temporally associated with the use of an investigational medicinal products (IMP). Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
Change From Baseline in Pulse (Week 68) Baseline (week 0), week 68 Change from baseline (week 0) in pulse at week 68 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
Change From Baseline in Diastolic Blood Pressure (Week 52) Baseline (week 0), week 52 Change from baseline (week 0) in diastolic blood pressure at week 52 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
Change From Baseline in Pulse (Week 52) Baseline (week 0), week 52 Change from baseline (week 0) in pulse at week 52 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
Change From Baseline in Diastolic Blood Pressure (Week 68) Baseline (week 0), week 68 Change from baseline (week 0) in diastolic blood pressure at week 68 are presented. Results are based on the data from the on-treatment observation period, which was the time period when a participant was on trial treatment, including any period after initiation of rescue medication.
Trial Locations
- Locations (181)
Elite Clinical Trials
🇺🇸Blackfoot, Idaho, United States
Solaris Clinical Research
🇺🇸Meridian, Idaho, United States
Cedar-Crosse Research Center
🇺🇸Chicago, Illinois, United States
Macoupin Research Group
🇺🇸Gillespie, Illinois, United States
Evanston Premier Hlthcr Res
🇺🇸Skokie, Illinois, United States
Midwest Inst For Clin Res
🇺🇸Indianapolis, Indiana, United States
Iowa Diab & Endo Res Center
🇺🇸West Des Moines, Iowa, United States
Cotton O'Neil Clin Research Ctr
🇺🇸Topeka, Kansas, United States
The Research Group of Lexington LLC
🇺🇸Lexington, Kentucky, United States
L-MARC Research Center
🇺🇸Louisville, Kentucky, United States
MD Medical Research
🇺🇸Oxon Hill, Maryland, United States
Brigham & Women's Hospital
🇺🇸Boston, Massachusetts, United States
MassResearch, LLC
🇺🇸Waltham, Massachusetts, United States
Aa Mrc Llc
🇺🇸Flint, Michigan, United States
Arcturus Healthcare, PLC.
🇺🇸Troy, Michigan, United States
Mercury Str Med Grp, PLLC
🇺🇸Butte, Montana, United States
Premier Research Inc.
🇺🇸Trenton, New Jersey, United States
Accellacare
🇺🇸Wilmington, North Carolina, United States
Lillestol Research LLC
🇺🇸Fargo, North Dakota, United States
Prestige Clinical Research
🇺🇸Franklin, Ohio, United States
Albert J Weisbrot
🇺🇸Mason, Ohio, United States
Intend Research
🇺🇸Norman, Oklahoma, United States
Corvallis Clinic PC Clinical Research Department
🇺🇸Corvallis, Oregon, United States
Preferred Primary Care Physicians_Pittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
Holston Medical Group Pc
🇺🇸Bristol, Tennessee, United States
Chattanooga Medical Research, LLC
🇺🇸Chattanooga, Tennessee, United States
Clinical Neuroscience Solutions
🇺🇸Memphis, Tennessee, United States
Arlington Family Res. Ctr Inc
🇺🇸Arlington, Texas, United States
Velocity Clinical Res-Dallas
🇺🇸Dallas, Texas, United States
Velocity Clinical Research, Dallas
🇺🇸Dallas, Texas, United States
UT Southwestern Med Cntr
🇺🇸Dallas, Texas, United States
Juno Research, LLC_Houston
🇺🇸Houston, Texas, United States
DCOL Ctr for Clin Res
🇺🇸Longview, Texas, United States
Research Institute Of Dallas
🇺🇸Plano, Texas, United States
VIP Trials
🇺🇸San Antonio, Texas, United States
Consano Clinical Research, LLC
🇺🇸Shavano Park, Texas, United States
York Clinical Research LLC
🇺🇸Norfolk, Virginia, United States
Dominion Medical Associates
🇺🇸Richmond, Virginia, United States
Capital Clin Res Ctr,LLC
🇺🇸Olympia, Washington, United States
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
Royal Brisbane and Women's Hospital
🇦🇺Herston, Queensland, Australia
Core Research Centre
🇦🇺Milton, Queensland, Australia
South Australian Endocrine Research
🇦🇺Keswick, South Australia, Australia
Southern Adelaide Diabetes & Endocrine Services
🇦🇺Oaklands Park, South Australia, Australia
Barwon Health (The Geelong Hospital)
🇦🇺Geelong, Victoria, Australia
"MHAT-Blagoevgrad", Department of Internal Diseases
🇧🇬Blagoevgrad, Bulgaria
Medical Center Zdrave Lom
🇧🇬Lom, Bulgaria
UMHAT Pulmed, Department of endocrinology
🇧🇬Pazardzhik, Bulgaria
"MHAT - Pazardzhik"
🇧🇬Pazardzhik, Bulgaria
OCSOMCE - Dr. Albena Dinkova EOOD
🇧🇬Pleven, Bulgaria
UMHAT "Kaspela", Depart. Endocrinology and Metab. Diseases
🇧🇬Plovdiv, Bulgaria
'MHAT Sveta Karidad' EAD
🇧🇬Plovdiv, Bulgaria
'MHAT Hadzhi Dimitar' OOD
🇧🇬Sliven, Bulgaria
"Medical center Smolyan clinical research" OOD
🇧🇬Smolyan, Bulgaria
UMHAT "Aleksandrovska"
🇧🇬Sofia, Bulgaria
USHATE "Akad. Ivan Penchev" Second Clinic of Endocrinology
🇧🇬Sofia, Bulgaria
Medical Institute of Ministry of interior
🇧🇬Sofia, Bulgaria
UMHAT Sveta Marina EAD
🇧🇬Varna, Bulgaria
AIPSMC Dr. Artin Magardichyan EOOD
🇧🇬Varna, Bulgaria
MHAT- Hristo Botev
🇧🇬Vratsa, Bulgaria
"MHAT "Sveti Panteleimon" - Yambol" AD
🇧🇬Yambol, Bulgaria
LMC Clin Res Inc. Calgary
🇨🇦Calgary, Alberta, Canada
C-endo Diab Endo Clin Calgery
🇨🇦Calgary, Alberta, Canada
G.A. Research Associates Ltd.
🇨🇦Moncton, New Brunswick, Canada
LMC ClinRsrh Inc.Brampton
🇨🇦Brampton, Ontario, Canada
LMC Clinical Res Thornhill
🇨🇦Concord, Ontario, Canada
LMC Endo Ctr (Etobicoke) Ltd
🇨🇦Etobicoke, Ontario, Canada
Wharton Med Clin Trials
🇨🇦Hamilton, Ontario, Canada
LMC Research Inc. Ottawa
🇨🇦Nepean, Ontario, Canada
LMC Oakville
🇨🇦Oakville, Ontario, Canada
Winterberry Family Medicine
🇨🇦Stoney Creek, Ontario, Canada
LMC Endo Centres Ltd.(Bayview)
🇨🇦Toronto, Ontario, Canada
Applied Med Inf Res
🇨🇦Montreal, Quebec, Canada
LMC Clin Rsrch Inc. (Montreal)
🇨🇦Saint-Laurent, Quebec, Canada
Poliklinika Solmed
🇭🇷Zagreb, Grad Zagreb, Croatia
KBC Rijeka, Endokrinologija
🇭🇷Rijeka, Primorsko - Goranska Županija, Croatia
Klinicki bolnicki centar Osijek
🇭🇷Osijek, Croatia
Opca bolnica Dr. Josip Bencevic
🇭🇷Slavonski Brod, Croatia
KB Dubrava, Zavod za endokrinologiju i dijabetes
🇭🇷Zagreb, Croatia
Klinicka bolnica Sveti Duh
🇭🇷Zagreb, Croatia
Ordinace pro choroby srdce
🇨🇿Chomutov, Czechia
Diahaza s.r.o.
🇨🇿Holešov, Czechia
DIALINE s.r.o.
🇨🇿Plzeň 3, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha, Czechia
Deenanath Mangeshkar Hospital & Research Centre
🇮🇳Pune, Maharashtra, India
Deenanath Mangeshkar Hospital and Research Centre
🇮🇳Pune, Maharashtra, India
Inamdar Multispeciality Hospital
🇮🇳Pune, Maharashtra, India
Apollo Hospital
🇮🇳Delhi, New Delhi, India
All India Institute of Medical Sciences
🇮🇳New Dehli, New Delhi, India
Dayanand Medical College & Hospital
🇮🇳Ludhiana, Punjab, India
Christian Medical College Hospital, Vellore
🇮🇳Vellore, Tamil Nadu, India
Osmania General Hospital
🇮🇳Hyderabad, Telangana, India
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Uniwersytecki Szpital w Krakowie
🇵🇱Krakow, Poland
Centrum Terapii Współczesnej J.M. Jasnorzewska S.K.A.
🇵🇱Lodz, Poland
Gaja Poradnie Lekarskie
🇵🇱Poznan, Poland
Centrum Medyczne "Diabetika"
🇵🇱Radom, Poland
NBR Polska Tomasz Klodawski
🇵🇱Warszawa, Poland
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji
🇵🇱Warszawa, Poland
Centrum Medyczne Oporow
🇵🇱Wroclaw, Poland
Prywatny Gabinet Janusz Gumprecht
🇵🇱Zabrze, Poland
Manati Ctr For Clin Research
🇵🇷Manati, Puerto Rico
DIADA, s.r.o.
🇸🇰Bardejov, Slovakia
Diabetologicka ambulancia Diabetes care, s.r.o.
🇸🇰Hnusta, Slovakia
Diabetologicka ambulancia DIAMO s.r.o.
🇸🇰Kezmarok, Slovakia
MOMED, s.r.o
🇸🇰Kralovsky Chlmec, Slovakia
IN-DIA s.r.o.
🇸🇰Lucenec, Slovakia
DIABETOL, s.r.o.
🇸🇰Presov, Slovakia
OLIVER - MED s.r.o.
🇸🇰Rimavska Sobota, Slovakia
MEDI-DIA s.r.o.
🇸🇰Sabinov, Slovakia
Diabetologicka ambulancia MUDr. Gabriela Zimova
🇸🇰Spisska Nova Ves, Slovakia
General Hospital Celje
🇸🇮Celje, Slovenia
Healthcare Centre Koper
🇸🇮Koper, Slovenia
UKC Ljubljana, Endocrinology and Diabetes
🇸🇮Ljubljana, Slovenia
UKC Maribor - diabetes
🇸🇮Maribor, Slovenia
Healtcare Centre Nova Gorica
🇸🇮Nova Gorica, Slovenia
Taichung Veterans General Hospital
🇨🇳Taichung City, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
SNZOZ Lege Artis
🇵🇱Bialystok, Poland
American Clinical Trials
🇺🇸Buena Park, California, United States
Valley Research
🇺🇸Fresno, California, United States
Velocity Clin Res San Diego
🇺🇸La Mesa, California, United States
First Valley Medical Group
🇺🇸Lancaster, California, United States
Pacific Clinical Studies
🇺🇸Los Alamitos, California, United States
Velocity Clin Res Wstlke
🇺🇸Los Angeles, California, United States
Desert Oasis Hlthcr Med Group
🇺🇸Palm Springs, California, United States
Gateway Research Center
🇺🇸Poway, California, United States
Encompass Clinical Research_Spring Valley
🇺🇸Spring Valley, California, United States
Diablo Clinical Research, Inc.
🇺🇸Walnut Creek, California, United States
San Fernando Valley Hlth Inst
🇺🇸West Hills, California, United States
Optumcare Colorado Springs
🇺🇸Colorado Springs, Colorado, United States
Chase Medical Research LLC
🇺🇸Waterbury, Connecticut, United States
Northeast Research Institute
🇺🇸Jacksonville, Florida, United States
San Marcus Res Clin Miami Lakes
🇺🇸Miami Lakes, Florida, United States
East West Med Res Inst
🇺🇸Honolulu, Hawaii, United States
Endo Res Solutions Inc
🇺🇸Roswell, Georgia, United States
Complete Health Research
🇺🇸Ormond Beach, Florida, United States
Diabetologická a endokrinologická ambulance Praha
🇨🇿Praha, Czechia
Private Endocrnologist Dr Viitas
🇪🇪Pärnu, Estonia
East Tallinn Central Hospital
🇪🇪Tallinn, Estonia
Merelahe Family Doctors Centre
🇪🇪Tallinn, Estonia
Estonian Diabetes Centre
🇪🇪Tallinn, Estonia
Centrum Kliniczno Badawcze
🇵🇱Elblag, Poland
Tartu University Hospital Internal Medicine Clinic
🇪🇪Tartu, Estonia
Centrum Badan Klinicznych PI-House
🇵🇱Gdansk, Poland
Institut für Klinische Forschung und Entwicklung
🇩🇪Berlin, Germany
Plassmann
🇩🇪Essen, Germany
Zentrum für klinische Forschung, Dr. med. Lüdemann
🇩🇪Falkensee, Germany
Diabetes Zentrum Wandsbek Berufsausuebungsgemeinschaft GbR
🇩🇪Hamburg, Germany
Wendisch/Dahl Hamburg
🇩🇪Hamburg, Germany
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose
🇩🇪Münster, Germany
RED-Institut für medizinische Forschung und Fortbildung GmbH
🇩🇪Oldenburg in Holstein, Germany
Praxis Dr. med. Wenzl-Bauer
🇩🇪Rehlingen-Siersburg, Germany
PTE-AOK II. Belgyogyaszati Klinika es Nephrologiai Centrum
🇭🇺Pécs, Baranya Vármegye, Hungary
Selye János Kórház és Rendelőintézet
🇭🇺Komárom, Komárom-Esztergom, Hungary
Óbudai Egészségügyi Centrum
🇭🇺Budapest, Hungary
Szőcs Depot Egészségügyi Szolgáltató Kft.
🇭🇺Budapest, Hungary
Fortis Hospital, Shalimar Bagh, New Delhi
🇮🇳New Delhi, Delhi, India
Bajcsy-Zsilinszky Kórház
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Központ Belgyógyászati Klinika D épület
🇭🇺Debrecen, Hungary
Debreceni Egyetem Klinikai Központ Belgyógyászati Klinika
🇭🇺Debrecen, Hungary
Markusovszky Egyetemi Oktatókórház
🇭🇺Szombathely, Hungary
Fejér Megyei Szent György Oktatókórház
🇭🇺Székesfehérvár, Hungary
Endolife Specialty Hospitals
🇮🇳Guntur, Andhra Pradesh, India
Care Outpatient Centre
🇮🇳Hyderabad, Andhra Pradesh, India
Nirmal Hospital Pvt. Ltd.
🇮🇳Surat, Gujarat, India
PGIMS Rohtak
🇮🇳Rohtak, Haryana, India
KLES & Prabhakar Kore Hospital and Research Centre
🇮🇳Belgaum, Karnatka, India
Amrita Institute Of Medical Sciences & Research Centre
🇮🇳Kochi, Kerala, India
Seth GS medical college and KEM Hospital
🇮🇳Mumbai, Maharashtra, India
Gandhi Hospital & Medical college
🇮🇳Hyderabad, Telengana, India
Gleneagles Hospitals
🇮🇳Hyderabad, Telengana, India
MV Hospital and Research Centre
🇮🇳Lucknow, Uttar Pradesh, India
I.P.G.M.E & R Hospital
🇮🇳Kolkata, West Bengal, India
Apollo Multispeciality Hospital, Kolkata
🇮🇳Kolkata, West Bengal, India
NZOZ Przychodnia Specjalistyczna Medica
🇵🇱Lublin, Lubelski, Poland
Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski
🇵🇱Gorzow Wielkopolski, Lubuskie, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
🇵🇱Bialystok, Podlaskie Voivodeship, Poland
NZOZ Specjalistyczny Osrodek Internistyczno-Diabetologiczny Małgorzata Arciszewska
🇵🇱Bialystok, Podlaskie, Poland
Kresmed Sp. z o. o.
🇵🇱Bialystok, Podlaskie, Poland
Centrum Zdrowia Metabolicznego
🇵🇱Poznan, Wielkopolskie Voivodeship, Poland
Osteo Medic s.c. Artur Racewicz Jerzy Supronik
🇵🇱Bialystok, Poland