Muscle mass loss and nutrition in critically ill childre

Not Applicable

Completed

• Conditions: Muscle mass loss during and after pediatric intensive care; Musculoskeletal Diseases; Muscle wasting and atrophy, not elsewhere classified

• Registration Number: ISRCTN81803039
• Lead Sponsor: Alder Hey Children's NHS Foundation Trust

Brief Summary

2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38554130/ (added 19/07/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-08
• Study Completion: 2023-09-30
• Last Update Posted: 29 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Invasively ventilated children (term neonate to 16 years)
2. Expected to stay >48 hours in PICU
3. Receiving some form of nutrition (enteral and/or parenteral)
4. Parents consent to the study
5. Normal neurologically
6. Of walking age
7. Independently ambulatory pre-admission
8. No previous PICU admission within the last 5 years
9. No known neuromuscular disease

Exclusion Criteria

Does not meet inclusion criteria

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. PICU muscle wasting assessed using ultrasound at days 1, 3, 5, 7 and 10 of PICU stay, hospital discharge and 3 months<br>2. Protein intake during critical illness assessed using nitrogen balance (g/day) from admission to PICU discharge