Ultrasonic Evaluation of Metoclopramide With or Without Dexamethasone on Gastric Motility in Traumatic Patients
Trial Snapshot
- Phase
- Phase 1
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 1
- Primary Endpoint
- Assessment of gastric weight/volume kg/m^2 measured by ultrasonography in traumatic patients.
Study Overview
Brief Summary
Reflux and the aspiration of gastric contents have always been important focal points. Previous study stated that trauma is an important factor in aspiration pneumonia.
Often, emergency trauma patients have residual gastric contents due to the ingestion of food before injury, the accidental swallowing of nasal and/or oral blood after injury, and delayed gastric emptying due to stress, pain, or the use of opioids.
During sedation or general anesthesia, such satiated patients are often at risk of aspiration due to a reduction in lower esophageal sphincter tension and the protective inhibition of the airway reflex.
Perioperative gastric ultrasound can be performed at a bedside ultrasound unit; it can safely, non-invasively, conveniently, and effectively evaluate the fullness of a patient's stomach and the nature of their gastric contents.
It can also be used in the selection of an appropriate method for the anesthetic induction process and can reduce the risk of vomiting, aspiration, and related complications.
As a gastric motility-promoting drug, metoclopramide can accelerate gastric emptying.
Dexamethasone reduced the incidence of nausea and vomiting and improve gastric motility.
Detailed Description
PATIENTS AND METHODS Study design / Prospective randomized controlled trial study sitting/this study will be conducted in Assiut University Trauma Center Hospital.
Patients will be randomly allocated into two groups:
- Group (1) : intravenous infusion of metoclopramide 8mg
- Group (2) : intravenous infusion of metoclopramide 8mg with infusion of dexamethasone 8mg INCLUSION CRITERIA
- Traumatic patients undergo emergency operations
- 18-60 years of age
- 155-180 cm in height
- Body mass index <30 kg/m2 EXCLUSION CRITERIA
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 16 Years to 50 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Traumatic patients undergo emergency operations
- •18-60 years of age
- •155-180 cm in height
- •Body mass index <30 kg/m2
Exclusion Criteria
- •A history of diseases of important organs, such as diabetes, gastro-paresis, liver and kidney dysfunction, and cardiopulmonary insufficiency.
- •Contraindications for metoclopramide or dexamethasone treatment.
- •Taking opioids or drugs that affect gastric motility.
- •A history of esophageal, gastric, or upper abdominal surgery.
- •A need for immediate emergency surgery, resulting in insufficient study time (120 min).
- •Inability of the patient or their family to understand the study protocol.
Outcomes
Primary Outcomes
Assessment of gastric weight/volume kg/m^2 measured by ultrasonography in traumatic patients.
Time Frame: 2 years
Assessment of gastric weight/volume kg/m\^2 by grams measured by ultrasonography in traumatic patients.
Secondary Outcomes
No secondary outcomes reported
Investigators
Ahmed Nassar Ibrahim Mohammed
Resident doctor
Assiut University