Monitoring of Delayed Ischemia After Subarachnoid Hemorrhage
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 1
研究概览
简要总结
The goal in this research is to develop better ways to detect and treat the damage caused by bleeding in the brain.
详细描述
Patients who suffer from a bleeding in the brain (stroke or hemorrhage) often experience secondary complications that can occur up to 2 weeks after the initial bleeding. Complications can include decrease of consciousness, weakness or paralysis, difficulty with speech and language, and worsening of brain damage. These decrease a patient's chances for a good recovery. A brain scan will be used to determine the damage caused by the bleeding, and the brain's electrical activity will be monitored to detect abnormal activity. These measures will be analyzed together with routine medical information to better understand and diagnose complications.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 to 70 years
- •World Federation of Neurosurgery (WFNS) grade III-IV, and grade V patients who improve within 24h after ventriculostomy
- •Diffuse thick or localized thick subarachnoid clot >1 mm on baseline CT (Fisher grade 3-4)
- •Ruptured saccular aneurysm demonstrated by CT-angiography or DSA
- •Onset of aSAH clinical symptoms within the preceding 72h
- •Treatment of aneurysm within 24 h after admission
- •Treatment of aneurysm by clip ligation
排除标准
- •SAH due to other causes (e.g. trauma, fusiform or mycotic aneurysm)
- •Only a thin diffuse layer or no visible subarachnoid blood in the initial CT
- •Admission in a clinical state with unfavourable prognosis (e.g., bilateral dilated, non-reactive pupils for more than 1h)
- •Coagulopathy (thrombocytes <60,000/ml or INR>1.5)
- •Presence of incompatibilities for MRI, such as non-removable metals, artificial joints, electronic devices (pace maker, pumps), etc.
研究者
Jed Hartings
Research Asst Professor
University of Cincinnati