Cardiopulmonary Effects of Intrathoracic Pressure Overshoot During Carbon Dioxide Insufflation in Thoracoscopic Surgery

Not Applicable

Completed

• Conditions: Esophageal Neoplasms
• Interventions: Device: Insufflation of carbon dioxide (CO2)

• Registration Number: NCT02330536
• Lead Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Brief Summary

Video-assisted thoracoscopic surgery (VATS) has become a standard technique for addressing all types of thoracic pathology. Insufflation of carbon dioxide (CO2) into the operated chest cavity could increase lung collapse and improve surgical field view. The actual thoracic pressure values may not be identical with the presetting on the insufflator display. This overshoot pressure during VATS may compromise cardiac and pulmonary function. The purpose of this study is to evaluate the effects of intrathoracic pressure overshoot during two-lung ventilation on the hemodynamic and respiratory function and clarify the relative safety of two different techniques of insufflation.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-12
• Study First Submitted: 2014-12-24
• Study First Submitted QC: 2015-01-02
• Study First Posted: 2015-01-05
• Primary Completion: 2020-07
• Study Completion: 2020-07
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-22
• Last Update Posted: 2021-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 232

Inclusion Criteria

• American Society of Anesthesiologists (ASA) Physical Status Ⅰ,Ⅱ
• Patients with esophageal carcinoma
• Elective video-assisted thoracic surgery

Exclusion Criteria

• Allergic to drugs used in the study
• Refusal of VAST
• Arrhythmia or treated with antiarrhythmic drug
• Surgery type were converted to thoracotomy,
• Massive intraoperative blood loss (> 400ml)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Flowrate A	Insufflation of carbon dioxide (CO2)	insufflation of carbon dioxide at 8L/min, 8mmHg
Flowrate B	Insufflation of carbon dioxide (CO2)	insufflation of carbon dioxide at 20 L/min, 8mmHg

Primary Outcome Measures

Name	Time	Method
thoracic pressure overshoot	one hour during CO2 insufflation	Time and value of thoracic pressure overshoot during CO2 insufflation
Hemodynamic change	one hour during CO2 insufflation	Hemodynamic changes during each overshoot including Systolic Blood Pressure, Central Venous Pressure and Heart Rate
Respiratory change	one hour during CO2 insufflation	Respiratory changes during each overshoot including Peak Inspiratory Pressure, Pressure flat, Arterial Oxygen Saturation and End-tidal Carbon dioxide