Radiomics-based Diagnosis, Treatment and Outcome Prediction for Pituitary Adenoma
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Recurrence rate of pituitary adenoma
研究概览
简要总结
The images of patients with Pituitary adenoma were collected and analyzed based on the methods of radiomics.
详细描述
Inclusion of pituitary adenoma patients diagnosed clinically or pathologically
- Clinical data and pre-treatment imaging data of included patients (DICOM format)
- Determine the subtype diagnosis of pituitary adenoma based on the patient's clinical and pathological data
- Collect relevant data of patients before and after treatment
- Using radiomics methods, extract radiomic features of patients and construct a radiomic model for predicting the diagnosis and treatment response of pituitary adenomas
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Gender unlimited, 18-80 years old;
- •Clinical diagnosis of Pituitary Adenoma and receive surgical treatment;
- •Received brain imaging;
- •informed consent signed
排除标准
- •Pregnant / lactating women
- •Contraindications of imaging examination
- •Lack of effective clinical data
- •MRI data before treatment cannot be obtained
- •Postoperative pathology not revealed pituitary adenoma
结局指标
主要结局
Recurrence rate of pituitary adenoma
时间窗: 1 year after treatment
The pituitary adenoma recurred 1 year after treatment. The recurrence was assessed by 3 aspects: (1)contrast enhanced MRI showed suspicious tumor growth, such as bone destruction; (2)signs and symptoms that had disappeared after treatment reappeared, such as pressing on nearby nerve tissue and some characteristic appearance; (3)endocrine indexes rose again after reaching the remission standard, iculding Prolactin(PRL)\>30 μg/L in Lactotroph adenoma; growth hormone (GH)\>2.5ng/ml in Somatotroph adenoma, serum cortisol\>800nmol/L at 8am in Corticotroph adenoma, while other types do not consider endocrine indicators.
次要结局
- Pathological type of pituitary adenomas(1 week after treatment)