Thermogenic Effect of Ginger

Not Applicable

Completed

• Conditions: Healthy Volunteers
• Interventions: Other: Extract of ginger; Other: Placebo (Cellulose)

• Registration Number: NCT03089593
• Lead Sponsor: Federal University of Minas Gerais

Brief Summary

The main objective of the study is to evaluate the thermogenic effect of ginger.

Detailed Description

Healthy and eutrophic women will receive capsules of 200 mg of ginger extract (5% active ingredient) or placebo (cellulose), along with a standardized breakfast, with a minimum seven days washout period.

Study Timeline

• Study First Submitted: 2017-03-08
• Study First Submitted QC: 2017-03-19
• Study First Posted: 2017-03-24
• Study Start: 2017-03-27
• Status Verified: 2017-06
• Primary Completion: 2017-06-14
• Study Completion: 2017-06-14
• Last Update Submitted: 2017-06-20
• Last Update Posted: 2017-06-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

• Females;
• Aged between 18 and 60 years old;
• Body mass index between 18.5 and 24.9 kg/m²;
• Agree to sign the informed consent.

Exclusion Criteria

• Any chronic health conditions (e.g. diabetes, hypertension, chronic renal failure, heart and liver disease);
• Previous operation for weight loss;
• Medications known to affect total energy expenditure;
• Pregnancy and breast-feeding;
• Smoking;
• Alcohol use (>2 doses/day).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Extract of ginger	Extract of ginger	Healthy and eutrophic women will receive two capsules of 200 mg of ginger extract (5% gingerols) to be taken along with a standardized breakfast.
Cellulose	Placebo (Cellulose)	Healthy and eutrophic women will receive two capsules of 200 mg of placebo (cellulose) to be taken along with a standardized breakfast.

Primary Outcome Measures

Name	Time	Method
Change in postprandial energy expenditure	Baseline and thereafter at 30, 60, 120, 180 and 240 minutes postprandial	Energy expenditure will be assessed by indirect calorimetry

Secondary Outcome Measures

Name	Time	Method
Change in oxygen consumption	Baseline and thereafter at 30, 60, 120, 180 and 240 minutes postprandial	Oxygen consumption will be assessed by indirect calorimetry
Change in blood pressure	Baseline and thereafter at 30, 60, 120, 180 and 240 minutes postprandial	Blood pressure will be assessed using digital sphygmomanometer
Change in axillary temperature	Baseline and thereafter at 30, 60, 120, 180 and 240 minutes postprandial	Axillary temperature will be assessed using a digital thermometer
Change in metabolic profile	Baseline and thereafter at 30, 60, 120 and 240 minutes postprandial	HDL-cholesterol
Change in heart rate	Baseline and thereafter at 30, 60, 120, 180 and 240 minutes postprandial	Heart rate will be assessed using digital sphygmomanometer

Trial Locations

Locations (1)

Hospital das Clínicas; 🇧🇷 Belo Horizonte, Minas Gerais, Brazil