Restoring Neural Oscillatory Communication Between Dorsal and Ventral Visual Streams in Developmental Dyslexia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Developmental Dyslexia
- Sponsor
- IRCCS Ospedale San Raffaele
- Enrollment
- 78
- Locations
- 1
- Primary Endpoint
- Reading score
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Developmental dyslexia (DD) is a multifactorial disorder that hampers the education of about 10% of individuals across cultures and is associated to both phonological and visual deficits. The latter have been linked to a deficit in the magnocellular-dorsal (M-D) visual stream, that has a critical role in guiding the activity of ventral visual stream areas where letters identity is extracted. Here, we will test the efficacy of transcranial alternate current stimulation (tACS) of the M-D stream combined with reading trainings in adult participants with DD, assessing the neurophysiological underpinnings of these new trainings with EEG and fMRI/DTI.
Investigators
Luca Ronconi
Professor
IRCCS Ospedale San Raffaele
Eligibility Criteria
Inclusion Criteria
- •Adult patient (age between 18 and 35)
- •Official Diagnosis of Developmental Dyslexia (DD)
- •Normal or corrected-to-normal vision and hearing
- •Normal motor skills
Exclusion Criteria
- •Participants that cannot sign the consent form
- •Participants unable to read or understand and correctly complete the procedures foreseen by the study
- •Participants with a diagnosis or personal history of epilepsy or patients with a positive family history of epilepsy
- •Pregnant or breastfeeding patients
- •Participants with major psychiatric or neurological disorders and/or currently in psychopharmacological treatments.
- •Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants.
- •Participants with claustrophobia (only for fMRI)
Outcomes
Primary Outcomes
Reading score
Time Frame: Pre-training, 1-7 days post-training, follow-up at 1 and 6 months
Text, word and pseudowords reading score