Restoring Neural Oscillatory Communication Between Dorsal and Ventral Visual Streams in Developmental Dyslexia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 2
- 主要终点
- Reading score
研究概览
简要总结
Developmental dyslexia (DD) is a multifactorial disorder that hampers the education of about 10% of individuals across cultures and is associated to both phonological and visual deficits. The latter have been linked to a deficit in the magnocellular-dorsal (M-D) visual stream, that has a critical role in guiding the activity of ventral visual stream areas where letters identity is extracted. Here, we will test the efficacy of transcranial alternate current stimulation (tACS) of the M-D stream combined with reading trainings in adult participants with DD, assessing the neurophysiological underpinnings of these new trainings with EEG and fMRI/DTI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult patient (age between 18 and 35)
- •Official Diagnosis of Developmental Dyslexia (DD)
- •Normal or corrected-to-normal vision and hearing
- •Normal motor skills
排除标准
- •Participants that cannot sign the consent form
- •Participants unable to read or understand and correctly complete the procedures foreseen by the study
- •Participants with a diagnosis or personal history of epilepsy or patients with a positive family history of epilepsy
- •Pregnant or breastfeeding patients
- •Participants with major psychiatric or neurological disorders and/or currently in psychopharmacological treatments.
- •Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants.
- •Participants with claustrophobia (only for fMRI)
结局指标
主要结局
Reading score
时间窗: Pre-training, 1-7 days post-training, follow-up at 1 and 6 months
Text, word and pseudowords reading score
次要结局
未报告次要终点
研究者
Luca Ronconi
Professor
IRCCS Ospedale San Raffaele