Portal Vein Thrombosis in Liver Cirrhosis: Clinical Characteristics, Radiological Patterns, and Predictors
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- Prevalence of Portal Vein Thrombosis (PVT)
研究概览
简要总结
Portal vein thrombosis (PVT) is a common complication in patients with liver cirrhosis and is associated with increased morbidity due to worsening portal hypertension and hepatic decompensation. The clinical presentation and radiological patterns of PVT vary widely, and the factors predicting its development remain incompletely understood.
This observational study will include adult patients (≥18 years) with established liver cirrhosis who are admitted to the Department of Gastroenterology and Tropical Medicine, Al-Rajhi Liver Hospital, Assiut University. Eligible participants will undergo routine screening for PVT using Doppler ultrasonography, with confirmation by contrast-enhanced computed tomography when indicated.
The study aims to evaluate the clinical characteristics, laboratory parameters, and radiological features of PVT. Cases of PVT will be classified according to extent (partial or complete) and anatomical location (main portal vein, right branch, left branch, or combined involvement). Clinical and laboratory data will be analyzed to identify potential predictors associated with the development and severity of PVT.
The findings of this study are expected to improve understanding of the risk factors and radiological patterns of PVT in cirrhotic patients, contributing to better risk stratification and clinical management.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with liver cirrhosis
排除标准
- •Patients with non-hepatic hemostatic disorders, active bacterial sepsis, renal dysfunction, peripheral or hepatic venous thrombosis, recent splenectomy, liver transplantation, antiplatelet or anticoagulant therapy or contraceptive pills were excluded.
研究组 & 干预措施
Group 1 (Patients): with PVT, Group 2 (Controls): without PVT
干预措施: Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed (Diagnostic Test)
结局指标
主要结局
Prevalence of Portal Vein Thrombosis (PVT)
时间窗: At baseline (during study enrollment period)
Proportion of cirrhotic patients diagnosed with portal vein thrombosis based on Doppler ultrasonography with confirmation by contrast-enhanced CT when indicated.
Predictors of Portal Vein Thrombosis
时间窗: Baseline assessment
Identification of clinical, laboratory, and radiological factors associated with the presence of PVT in cirrhotic patients
次要结局
- Association Between PVT Type and Clinical Parameters(At time of diagnosis)
- Radiological Pattern of PVT(At time of PVT diagnosis)
研究者
Elham Ahmed Hassan
Professor of Gastroenterology and Tropical Medicine
Assiut University