Prognosis of Heart Transplanted Patients With Heart Failure

Recruiting

• Conditions: Heart Failure

• Registration Number: NCT05775432
• Lead Sponsor: First Affiliated Hospital Xi'an Jiaotong University

Brief Summary

Heart transplantation is the most effective treatment for end-stage heart failure, advanced cardiomyopathy, and complex congenital heart disease with severe heart failure or hypoxia. Several clinical studies have shown significant differences in the prognosis of heart transplantation patients with different etiologies, and post-transplantation complications are an important factor affecting patient survival, and there is still a lack of overall prognostic stratification and extensive clinical studies on risk factors after heart transplantation. Therefore, this study is intended to include patients who underwent heart transplantation for different etiologies of heart failure, collect clinical data and biological samples from patients, and use various techniques to deeply interpret the risk factors affecting the prognosis of heart transplantation patients and construct a prognostic prediction model to provide specific and individualized treatment ideas and theoretical basis for improving the survival rate of patients after heart transplantation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-02-14
• Study First Submitted QC: 2023-03-16
• Study First Posted: 2023-03-20
• Study Start: 2023-04-23
• Status Verified: 2024-03
• Last Update Submitted: 2024-07-10
• Last Update Posted: 2024-07-12
• Primary Completion: 2042-12-31
• Study Completion: 2042-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Patients with end-stage heart failure presented to our hospital who are evaluated by clinicians and ethically approved for heart transplantation
• Individuals whose hearts are donated

Exclusion Criteria

• Patients refuse to sign informed consent form

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in the incidence of all-cause death	In-hospital (an average of 1 month), 1, 2, 3, 5, 10, 15 and 20 years after heart transplantation.	Death from any cause in patients after heart transplantation, will be assessed from medical records.

Secondary Outcome Measures

Name	Time	Method
Incidence of postoperative complications	In-hospital (an average of 1 month)	Postoperative complications after heart transplantation will be assessed from medical records.
Use of advanced life support (ALS)	In-hospital (an average of 1 month)	Duration of ALS after heart transplantation, will be assessed from medical records.
Change of cardiac function index	In-hospital (an average of 1 month).	Cardiac functional index after heart transplantation will be assessed by transthoracic echocardiography.
ICU admission time	In-hospital (an average of 1 month)	ICU admission time after heart transplantation, will be assessed from medical records.

Trial Locations

Locations (1)

First Affiliated Hospital of Xi'an Jiaotong University; 🇨🇳 Xi'an, Shaanxi, China