Prognosis of Heart Transplanted Patients With Heart Failure (RE-START): a National Multi-center, Retrospective-prospective, Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Change in the incidence of all-cause death
研究概览
简要总结
Heart transplantation is the most effective treatment for end-stage heart failure, advanced cardiomyopathy, and complex congenital heart disease with severe heart failure or hypoxia. Several clinical studies have shown significant differences in the prognosis of heart transplantation patients with different etiologies, and post-transplantation complications are an important factor affecting patient survival, and there is still a lack of overall prognostic stratification and extensive clinical studies on risk factors after heart transplantation. Therefore, this study is intended to include patients who underwent heart transplantation for different etiologies of heart failure, collect clinical data and biological samples from patients, and use various techniques to deeply interpret the risk factors affecting the prognosis of heart transplantation patients and construct a prognostic prediction model to provide specific and individualized treatment ideas and theoretical basis for improving the survival rate of patients after heart transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 3 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with end-stage heart failure presented to our hospital who are evaluated by clinicians and ethically approved for heart transplantation
- •Individuals whose hearts are donated
排除标准
- •Patients refuse to sign informed consent form
结局指标
主要结局
Change in the incidence of all-cause death
时间窗: In-hospital (an average of 1 month), 1, 2, 3, 5, 10, 15 and 20 years after heart transplantation.
Death from any cause in patients after heart transplantation, will be assessed from medical records.
次要结局
- Incidence of postoperative complications(In-hospital (an average of 1 month))
- Use of advanced life support (ALS)(In-hospital (an average of 1 month))
- Change of cardiac function index(In-hospital (an average of 1 month).)
- ICU admission time(In-hospital (an average of 1 month))