Acute Kidney Injury in critically ill infants

Completed

• Conditions: Acute Kidney Injury; 10038430

• Registration Number: NL-OMON38246
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 390

Inclusion Criteria

- Age: Up to 12 months
- Group 1: - Patients admitted for minor surgical procedures with stable hemodynamics and normal kidney function: term up to 1 year of age
- Group 2: - Critical illness: mechanical ventilation
- Need for vasopressor drugs
- Group 3: - Critically ill patients with ECMO treatment
- Group 4: - Neonates admitted for minor surgical procedures with stable hemodynamics and normal kidney function: 32 up to 37 weeks of gestational age

Exclusion Criteria

- No informed consent
- Pre-existent kidney disease or kidney anomaly on ultrasound
- Group 1 and 4: Use of known nephrotoxic drugs, like aminoglycosides
pRIFLE score showing AKI
- Group 1, 2, 3: Preterm birth
- Group 4: Preterm birth before 32 weeks of gestational age

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. To assess reference values of a pre-defined set of biomarkers for AKI in<br /><br>*surgical* infants with normal kidney function.<br /><br>2. To evaluate the sensitivity and specificity of these biomarkers in<br /><br>predicting AKI as well as the incidence of AKI in critically ill infants.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>None</p><br>