Effect of Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli
Not Applicable
- Conditions
- Glucose ControlBrain Activity
- Registration Number
- NCT02969330
- Lead Sponsor
- Tel Aviv University
- Brief Summary
The aims of this study are twofold: (1) to develop an innovative approach for studying brain glucose metabolism using functional diffusion weighted imaging (DWI) and BOLD fMRI in humans; (2) to evaluate the effect of short peripheral electrical stimulation (PES) treatment on brain and brain-stem targets, associated with control of food intake and energy expenditure, in response to glucose stimuli, in healthy volunteers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Healthy volunteers
- Age 18-65 years old.
- Body mass index 18 to 25 kg/m2
- Capable of giving informed consent
Exclusion Criteria
- Pregnancy, or nursing
- Permanent pacemakers
- Metal prosthesis
- Skin disease
- Claustrophobia
- History of neurological disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Changes in postprandial cerebral blood flow (fMRI) and cerebral diffusivity (fDWI) in response to glucose ingestion. changes from baseline to 30 minutes after glucose ingestion
- Secondary Outcome Measures
Name Time Method