Effect of Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli

Not Applicable

• Conditions: Glucose Control; Brain Activity
• Interventions: Device: Stimulator; Dietary Supplement: Glucose

• Registration Number: NCT02969330
• Lead Sponsor: Tel Aviv University

Brief Summary

The aims of this study are twofold: (1) to develop an innovative approach for studying brain glucose metabolism using functional diffusion weighted imaging (DWI) and BOLD fMRI in humans; (2) to evaluate the effect of short peripheral electrical stimulation (PES) treatment on brain and brain-stem targets, associated with control of food intake and energy expenditure, in response to glucose stimuli, in healthy volunteers.

Detailed Description

Not available

Study Timeline

• Status Verified: 2016-11
• Study First Submitted: 2016-11-17
• Study First Submitted QC: 2016-11-17
• Last Update Submitted: 2016-11-17
• Study First Posted: 2016-11-21
• Last Update Posted: 2016-11-21
• Study Start: 2016-12
• Primary Completion: 2018-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Healthy volunteers
• Age 18-65 years old.
• Body mass index 18 to 25 kg/m2
• Capable of giving informed consent

Exclusion Criteria

• Pregnancy, or nursing
• Permanent pacemakers
• Metal prosthesis
• Skin disease
• Claustrophobia
• History of neurological disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
PES	Stimulator	Single session of short PES treatment before glucose ingestion.
Glucose	Glucose	Glucose ingestion
PES	Glucose	Single session of short PES treatment before glucose ingestion.

Primary Outcome Measures

Name	Time	Method
Changes in postprandial cerebral blood flow (fMRI) and cerebral diffusivity (fDWI) in response to glucose ingestion.	changes from baseline to 30 minutes after glucose ingestion