Effect of Short Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli Evaluated by BOLD and Functional Diffusion MRI: a Crossover Pilot Study
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- Changes in postprandial cerebral blood flow (fMRI) and cerebral diffusivity (fDWI) in response to glucose ingestion.
研究概览
简要总结
The aims of this study are twofold: (1) to develop an innovative approach for studying brain glucose metabolism using functional diffusion weighted imaging (DWI) and BOLD fMRI in humans; (2) to evaluate the effect of short peripheral electrical stimulation (PES) treatment on brain and brain-stem targets, associated with control of food intake and energy expenditure, in response to glucose stimuli, in healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Age 18-65 years old.
- •Body mass index 18 to 25 kg/m2
- •Capable of giving informed consent
排除标准
- •Pregnancy, or nursing
- •Permanent pacemakers
- •Metal prosthesis
- •Skin disease
- •Claustrophobia
- •History of neurological disorders
研究组 & 干预措施
PES
Single session of short PES treatment before glucose ingestion.
干预措施: Stimulator (Device)
PES
Single session of short PES treatment before glucose ingestion.
干预措施: Glucose (Dietary Supplement)
Glucose
Glucose ingestion
干预措施: Glucose (Dietary Supplement)
结局指标
主要结局
Changes in postprandial cerebral blood flow (fMRI) and cerebral diffusivity (fDWI) in response to glucose ingestion.
时间窗: changes from baseline to 30 minutes after glucose ingestion
次要结局
未报告次要终点