Approach to a quantitative follow-up of non-thyroidal illness syndrome

• Conditions: E07.8; Other specified disorders of thyroid

• Registration Number: DRKS00003152
• Lead Sponsor: Wissenschaftskommission des Universitätsklinikums Bergmannsheil

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-07-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 585

Inclusion Criteria

Severe illness requiring intensive care; stay of at least 24 hours at the IC

Exclusion Criteria

Substituted hypothyroidism or substitution in case of thyroid carcinoma; hyperthyroidism that is treated with thyrostatic agents and exhibits a TSH level not below the reference region; manifest AIDS disease; pregnancy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment of the significance of an innovative physiological index approach (SPINA) in differential diagnosis between NTIS and latent thyrotoxicosis. [Time Frame: Three weeks after admission to ICU (evaluation point 1.5) and additionally on day of discharge from the hospital (evaluation point 1.999)]: Diagnostic accuracy (sensitivity, specificity and AUCs of ROC analysis) of the thyroid's calculated secretory capacity (GT) for differentiation between NTIS and subclinical hyperthyroidism.

Secondary Outcome Measures

Name	Time	Method
Correlation of variables that quantify distinct components of NTIS with independent predictors of evolution, survival or pathophysiological condition and influencing or disturbing factors like medication. [Time Frame: 24 hours (evaluation point 1.1), 72 hours (evaluation point 1.2) and further on weekly (evaluation points 1.3 to 1.5) after admission to the intensive care unit up to the day of discharge from hospital (evaluation point 1.999)]