Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension: A Prospective Randomised Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Propofol Induced Hypotension
- Sponsor
- Nitte University
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- incidence of hypotension at baseline
- Last Updated
- 9 years ago
Overview
Brief Summary
Propofol is an intravenous anaesthetic agent used for both induction and maintenance of anaesthesia. An important adverse effect is the significant fall in blood pressure. The current clinical study will be done to determine the efficacy of leg elevation and wrapping in reducing the incidence and severity of propofol induced hypotension in patients undergoing general anaesthesia.
Detailed Description
Propofol is an intravenous anaesthetic agent used for both induction and maintenance of anaesthesia. It is widely employed due to its quick onset of action, short half life and rapid recovery. An important adverse effect is the significant fall in blood pressure. Although the exact mechanism of propofol induced hypotension is not known, venodilation, decreased peripheral resistance and decrease in cardiac output has been suggested.2 Though the hypotension is transient, it can produce devastating effects. Hence there is a need to prevent it. Moreover, several attempts at treating propofol induced hypotension have been met with variable and limited success. Hypotension following spinal anaesthesia is also a frequent problem. It is generally treated with intravenous fluids and vasopressors. Simple and non pharmacological measures like leg elevation and leg wrapping with Esmarch bandage were reported to be successful.3 These reduce the incidence and severity of hypotension associated with spinal anaesthesia by improving the venous return. The mechanisms of hypotension following intravenous propofol and spinal anaesthesia are almost similar. Therefore, the investigators hypothesize that leg elevation and wrapping can be attempted to reduce propofol induced hypotension. They are simple and cost effective techniques that will reduce the need for pharmacological measures to control hypotension. As the literature search did not reveal any information regarding the usefulness of these techniques in propofol induced hypotension, the current clinical study will be done to determine the efficacy of leg elevation and wrapping in reducing the incidence and severity of propofol induced hypotension in patients undergoing general anaesthesia. The current study will compare the efficacy of leg elevation and leg wrapping in reducing the incidence and severity of propofol induced hypotension in terms of incidence of hypotension, magnitude of decrease in systolic, diastolic and mean arterial blood pressures, need for pharmacological measures to treat hypotension, changes in heart rate and adverse clinical outcomes, if any. It will be a prospective randomised controlled open label study from January 2016 to August 2017 involving 150 adult patients undergoing general anaesthesia. For statistical analysis, descriptive statistics - minimum, maximum, mean and standard deviation will be used. Independent sample t test for data following normal distribution and for data not following normal distribution, Mann-Whitney U test will be used. P value less than 0.05 will be considered statistically significant. To study relationship between hypotension and other variables, Pearson's correlation will be used. Confidence interval will be calculated to 95%.
Investigators
Dr. Sara Jaison
Junior Resident
Nitte University
Eligibility Criteria
Inclusion Criteria
- •Patients belonging to ASA physical status I and II undergoing endotracheal general anaesthesia
Exclusion Criteria
- •Patient refusal
- •Contraindication to application of bandage
- •Partial or complete limb amputation
- •Difficult airway
- •Use of extraglottic airway device
- •Pregnancy
- •On antihypertensive or vasoactive medication
- •Autonomic neuropathy
Outcomes
Primary Outcomes
incidence of hypotension at baseline
Time Frame: baseline
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 0 minutes after leg elevation or wrapping
Time Frame: 0 minutes after leg elevation or wrapping
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 0 minutes after induction with propofol
Time Frame: 0 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 1 minute after induction
Time Frame: 1 minute after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 2 minutes after induction
Time Frame: 2 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 3 minutes after induction
Time Frame: 3 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 4 minutes after induction
Time Frame: 4 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 5 minutes after induction
Time Frame: 5 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 0 minutes after intubation
Time Frame: 0 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 1 minute after intubation
Time Frame: 1 minute after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 2 minutes after intubation
Time Frame: 2 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 3 minutes after intubation
Time Frame: 3 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 4 minutes after intubation
Time Frame: 4 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 5 minutes after intubation
Time Frame: 5 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 6 minutes after intubation
Time Frame: 6 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 7 minutes after intubation
Time Frame: 7 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 8 minutes after intubation
Time Frame: 8 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 9 minutes after intubation
Time Frame: 9 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
incidence of hypotension at 10 minutes after intubation
Time Frame: 10 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP \<60mm Hg. Incidence of hypotension will be noted.
Secondary Outcomes
- Magnitude of change in systolic blood pressure from baseline at 0 minutes after leg leg elevation or wrapping(baseline, after leg elevation or wrapping)
- Magnitude of change in systolic blood pressure from baseline at 0 minutes after induction(baseline, at 0 minutes after induction with propofol)
- Magnitude of change in systolic blood pressure from baseline at 1 minute after induction(baseline, at 1 minute after induction with propofol)
- Magnitude of change in systolic blood pressure from baseline at 2 minutes after induction(baseline, at 2 minutes after induction with propofol)
- Magnitude of change in systolic blood pressure from baseline at 3 minutes after induction(baseline, at 3 minutes after induction with propofol)
- Magnitude of change in systolic blood pressure from baseline at 4 minutes after induction(baseline, at 4 minutes after induction with propofol)
- Magnitude of change in systolic blood pressure from baseline at 5 minutes after induction(baseline, at 5 minutes after induction with propofol)
- Magnitude of change in systolic blood pressure from baseline at 0 minutes after intubation(baseline, at 0 minutes after intubation)
- Magnitude of change in systolic blood pressure from baseline at 1 minute after intubation(baseline, at 1 minute after intubation)
- Magnitude of change in systolic blood pressure from baseline at 2 minutes after intubation(baseline, at 2 minutes after intubation)
- Magnitude of change in systolic blood pressure from baseline at 3 minutes after intubation(baseline, at 3 minutes after intubation)
- Magnitude of change in systolic blood pressure from baseline at 4 minutes after intubation(baseline, at 4 minutes after intubation)
- Magnitude of change in systolic blood pressure from baseline at 5 minutes after intubation(baseline, at 5 minutes after intubation)
- Magnitude of change in systolic blood pressure from baseline at 6 minutes after intubation(baseline, at 6 minutes after intubation)
- Magnitude of change in systolic blood pressure from baseline at 7 minutes after intubation(baseline, at 7 minutes after intubation)
- Magnitude of change in systolic blood pressure from baseline at 8 minutes after intubation(baseline, at 8 minutes after intubation)
- Magnitude of change in systolic blood pressure from baseline at 9 minutes after intubation(baseline, at 9 minutes after intubation)
- Magnitude of change in systolic blood pressure from baseline at 10 minutes after intubation(baseline, at 10 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 0 minutes after leg elevation or wrapping(baseline, at 0 minutes after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation)
- Magnitude of change in diastolic blood pressure from baseline at 0 minutes after induction with propofol(baseline, at 0 minutes after induction with propofol)
- Magnitude of change in diastolic blood pressure from baseline at 1 minute after induction with propofol(baseline, at 1 minute after induction with propofol)
- Magnitude of change in diastolic blood pressure from baseline at 2 minutes after induction with propofol(baseline, at 2 minutes after induction with propofol)
- Magnitude of change in diastolic blood pressure from baseline at 3 minutes after induction with propofol(baseline, at 3 minutes after induction with propofol)
- Magnitude of change in diastolic blood pressure from baseline at 4 minutes after induction with propofol(baseline, at 4 minutes after induction with propofol)
- Magnitude of change in diastolic blood pressure from baseline at 5 minutes after induction with propofol(baseline, at 5 minutes after induction with propofol)
- Magnitude of change in diastolic blood pressure from baseline at 0 minutes after intubation(baseline, at 0 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 1 minute after intubation(baseline, at 1 minute after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 2 minutes after intubation(baseline, at 2 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 3 minutes after intubation(baseline, at 3 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 4 minutes after intubation(baseline, at 4 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 5 minutes after intubation(baseline, at 5 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 6 minutes after intubation(baseline, at 6 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 7 minutes after intubation(baseline, at 7 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 8 minutes after intubation(baseline, at 8 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 9 minutes after intubation(baseline, at 9 minutes after intubation)
- Magnitude of change in diastolic blood pressure from baseline at 10 minutes after intubation(baseline, at 10 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 0 minutes after leg elevation or wrapping(baseline, 0 minutes after leg elevation or wrapping)
- Magnitude of change in mean arterial blood pressure from baseline at 1 minute after induction with propofol(baseline, 0 minute after induction with propofol)
- Magnitude of change in mean arterial blood pressure from baseline at 2 minutes after induction with propofol(baseline, 2 minutes after induction with propofol)
- Magnitude of change in mean arterial blood pressure from baseline at 3 minutes after induction with propofol(baseline, 3 minutes after induction with propofol)
- Magnitude of change in mean arterial blood pressure from baseline at 4 minutes after induction with propofol(baseline, 4 minutes after induction with propofol)
- Magnitude of change in mean arterial blood pressure from baseline at 5 minutes after induction with propofol(baseline, 5 minutes after induction with propofol)
- Magnitude of change in mean arterial blood pressure from baseline at 0 minute after intubation(baseline, 0 minute after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 1 minutes after intubation(baseline, 1 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 2 minutes after intubation(baseline, 2 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 3 minutes after intubation(baseline, 3 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 4 minutes after intubation(baseline, 4 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 5 minutes after intubation(baseline, 5 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 6 minutes after intubation(baseline, 6 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 7 minutes after intubation(baseline, 7 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 8 minutes after intubation(baseline, 8 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 9 minutes after intubation(baseline, 9 minutes after intubation)
- Magnitude of change in mean arterial blood pressure from baseline at 10 minutes after intubation(baseline, 10 minutes after intubation)
- changes in heart rate from baseline at 0 minutes after leg elevation or wrapping(baseline, 0 minutes after leg elevation or wrapping)
- changes in heart rate from baseline at 0 minutes after induction with propofol(baseline, 0 minute after induction with propofol)
- changes in heart rate from baseline at 1 minutes after induction with propofol(baseline, 1 minutes after induction with propofol)
- changes in heart rate from baseline at 2 minutes after induction with propofol(baseline, 2 minutes after induction with propofol)
- changes in heart rate from baseline at 3 minutes after induction with propofol(baseline, 3 minutes after induction with propofol)
- changes in heart rate from baseline at 4 minutes after induction with propofol(baseline, 4 minutes after induction with propofol)
- changes in heart rate from baseline at 5 minutes after induction with propofol(baseline, 5 minutes after induction with propofol)
- changes in heart rate from baseline at 0 minutes after intubation(baseline, 0 minutes after intubation)
- changes in heart rate from baseline at 1 minute after intubation(baseline, 1 minute after intubation)
- changes in heart rate from baseline at 2 minutes after intubation(baseline, 2 minutes after intubation)
- changes in heart rate from baseline at 3 minutes after intubation(baseline, 3 minutes after intubation)
- changes in heart rate from baseline at 4 minutes after intubation(baseline, 4 minutes after intubation)
- changes in heart rate from baseline at 5 minutes after intubation(baseline, 5 minutes after intubation)
- changes in heart rate from baseline at 6 minutes after intubation(baseline, 6 minutes after intubation)
- changes in heart rate from baseline at 7 minutes after intubation(baseline, 7 minutes after intubation)
- changes in heart rate from baseline at 8 minutes after intubation(baseline, 8 minutes after intubation)
- changes in heart rate from baseline at 9 minutes after intubation(baseline, 9 minutes after intubation)
- changes in heart rate from baseline at 10 minutes after intubation(baseline, 10 minutes after intubation)