Cohort of Neurovascular Diseases Treated in the Acute Phase and Followed at Lariboisière

Not yet recruiting

• Conditions: Hemorrhagic Stroke; Ischemic Stroke
• Interventions: Other: follow-up

• Registration Number: NCT06026696
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

Neurovascular diseases can cause ischaemic or haemorrhagic strokes. While the most common, such as atherosclerosis are widely studied, others are less well known, such as arterial dissections or cerebral angiopathies. What's more, most studies are limited to a few years' follow-up and the longer-term evolution of patients is less well assessed. Patient follow-up data available in routine practice and specific enrollment through the headache emergencies of the Lariboisière neurovascular intensive care unit (USINV) could provide a particularly rich resource.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-07
• Study First Submitted: 2023-08-21
• Study Start: 2023-09
• Study First Submitted QC: 2023-09-04
• Last Update Submitted: 2023-09-04
• Study First Posted: 2023-09-07
• Last Update Posted: 2023-09-07
• Primary Completion: 2033-09
• Study Completion: 2038-09

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

1. Adult patients ≥18 years
2. Patients admitted to the Neurovascular Intensive Care Unit with acute cerebrovascular disease OR Patients managed for acute cerebrovascular pathology with or without stroke by the Lariboisière neurology team.
3. No opposition from the patient to the research and for patients under guardianship or guardianship or lack of capacity to object (severe impairment of cognitive functions, dementia, etc.), no opposition from the legal representative.

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Exclusion Criteria

1. Patient refusing to take part in the study or refusal by the legal representative in the case of patients under guardianship or curatorship
2. Patient suffering from a rare neurovascular disease and being followed at the "Centre de référence des maladies vasculaires rares du cerveau et de l'oeil" (CERVCO)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients treated for acute cerebrovascular pathology cerebrovascular disease	follow-up	-

Primary Outcome Measures

Name	Time	Method
Incidence of a vascular event	Up to 5 years	Vascular event is defined as : myocardial infarction, ischaemic or haemorrhagic stroke, recurrence of cerebrovascular disease, systemic embolism, congestive heart disease, vascular or non-vascular death during patient follow-up.

Secondary Outcome Measures

Name	Time	Method
Modified Rankin score	At 10 years	The modified Rankin score is a 6 point disability scale varying between 0 to 5. The higher the score, the greater the disability.
Obstetrical prognosis	Up to 10 years	Incidence of pregnancies, complications, delivery methods
Incidence of a vascular event	Up to 10 years	Vascular event is defined as : myocardial infarction, ischaemic or haemorrhagic stroke, recurrence of cerebrovascular disease, systemic embolism, congestive heart disease, vascular or non-vascular death during patient follow-up.
Number of adverse events	Up to 10 years	Evaluation of treatment tolerance
Prevalence of vascular risk factors	Up to 10 years	Medical history, LDL (Low Density Lipoprotein), Tobacco, Arterial pressure, HbA1C (glycated hemoglobin)
Treatment adherence	Up to 10 years
Occurrence of intercurrent pathologies requiring specific treatment	Up to 10 years	Pathologies are defined as : anxiety-depressive disorder, dementia, comititude, neoplasia, venous thromboembolism, haemorrhage, systemic disease, respiratory insufficiency
Incidence of headaches	Up to 10 years
Incidence of death	Up to 10 years	Age and causes of death
Number of associated treatments	Up to 10 years	Description of the types of treatment used