Effect of nano-silver mouthwash on white spot lesion, gingival status and inflammatory biomarkers in patients undergoing fixed braces. (randomized double blind clinical trial)

Not Applicable

Conditions: Enamel demineralization and gingivitis in orthodontic patients.
patients with fixed orthodontic appliance
Z 46.4

Registration Number: IRCT20190611043870N1

Lead Sponsor: The University of Sulaimani

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 42

Inclusion Criteria

Full fixed appliance treatment involving upper and lower dentitions for a minimum of six months duration.
Mild (up to 3mm spacing) to moderate (4-6mm space required) class l malocclusion.
Age group rang from 18-40 years of age.
Good oral hygiene
Non-extraction treatment plan
Healthy, non-smoker with no systemic medical conditions and no routine medications

Exclusion Criteria

Antibiotic use during preceding month.
Patients who received antibiotics prophylaxis or any systematic medication within 3 months prior to the study.
Patients who take medications that affect salivary flow (e.g. antidepressant, diuretics, antihistamines, narcotics and B adrenorecepter agonist).
Smokers.
Evidence of periodontitis.
Dentofacial deformities (cleft palate, hemifacial,microsomia, etc….)
Pregnant and lactating women.
patient with clinical signs of gingivitis.
patient with systematic disorder that could alter the periodontal conditions prior to bracket bonding.
Presence of impacted teeth.
Presence of pretreatment white spot lesions.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
White spot lesion. Timepoint: before intervention, 30 days, 90 days and 180 days after intervention. Method of measurement: photography.;Gingival status. Timepoint: before intervention,24 hours, 30 days, 90 days and 180 days after intervention. Method of measurement: clinical examination.;Inflammatory biomarkers. Timepoint: before intervention, 24 hours, 30 days, 90 days and 180 days after intervention. Method of measurement: ELISA test.

Secondary Outcome Measures