Fish Oil Supplementation in Cancer Patients - Capsules or in Nutritional Supplements. A Controlled Trial of Compliance.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- Compliance
研究概览
简要总结
Several studies indicate beneficial effects of eicosapentanoic acid (EPA) on cancer cachexia. However, compliance is generally low. This case control study is conducted in order to investigate if compliance depends upon the physical properties of the supplement (capsules vs. drinks). In order to further investigate how compliance can be improved, a possible correlation between sideeffects and rate of increased polyunsaturated fatty acid concentration in blood is also tested
详细描述
Patients with abdominal cancer in active chemotherapeutic were allocated to either EPA in an oral nutritional drink (commercial) or capsules with fish oil. The dose of EPA was the same in both groups, and diets were adjusted as iso-caloric. Compliance to the fish oil treatment was the primary outcome. Blood concentrations of EPA secondary.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
盲法说明
pseudo-anonymized
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients receiving chemotherapy on Rigshospitalet due to colorectal cancer
- •Not terminally ill
- •Subjects must be18 years of age (or older)
排除标准
- •Subjects who do not read/speak/understand Danish
- •Familial hypercholesterolemia
- •Predialytic patients (GFR < 15 ml/min/1,73 m2 or creatinine ≥ 500 mmol/L)
- •Use of blood thinners
- •Bleeder's disease
研究组 & 干预措施
Capsules
Dietary Supplement: Möllers Omega-3 Ekstra Sterk
干预措施: Möllers Omega-3 Ekstra Sterk (Dietary Supplement)
Drink
Dietary Supplement: Nutrifriend Cachexia
干预措施: Nutrifriend Cachexia (Dietary Supplement)
结局指标
主要结局
Compliance
时间窗: 4 weeks
Number of Capsules and bottles counted
次要结局
- Erythrocyte concentration of EPA(4 weeks)
研究者
Jens Rikardt Andersen
Associated Professor
University of Copenhagen