Comparison of the Effects of Intrathecal Morphine at Two Different Doses in Thoracoscopic Lung Resection
Overview
- Phase
- Phase 4
- Intervention
- Morphine
- Conditions
- Postoperative Pain
- Sponsor
- Cukurova University
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- pain scores
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Thoracic surgery is one of the surgeries where postoperative pain is intense. In this study, the investigators aimed to compare the efficacy of two different intrathecal morphine doses administered for postoperative analgesia according to patients' ideal body weight.
Detailed Description
Patients who underwent video-assisted thoracic surgery were divided into two groups: 10 mcg/kg and 7 mcg/kg intrathecal morphine for postoperative analgesia. Intraoperative and postoperative hemodynamic variables, postoperative morphine consumption, postoperative pain scores, side effects and additional analgesic requiretment were recorded.
Investigators
mediha turktan
associate professor
Cukurova University
Eligibility Criteria
Inclusion Criteria
- •\> 18 years old
- •ASA class I and II
- •Video-assisted thoracoscopic surgery
Exclusion Criteria
- •\< 18 years old
- •ASA class \> II
- •Serious hepatic, cardiac, renal, metabolic, endocrine diseases
- •Coagulation disfunction
- •Allergy to any of the study drugs
- •Pneumonectomy
- •Infection in the lumbar region
Arms & Interventions
7 mcg/kg intrathecal morphine
For postoperative analgesia, before surgical incision 7 mcg/ideal body weight morphine HCl (in 2 ml volume) was administered intrathecally at L4-5 interspace in the lateral decubitis position.
Intervention: Morphine
10 mcg/kg intrathecal morphine
For postoperative analgesia, before surgical incision, 10 mcg/ideal body weight morphine HCl (in 2 ml volume) was administered intrathecally at L4-5 interspace in the lateral decubitis position.
Intervention: Morphine
Outcomes
Primary Outcomes
pain scores
Time Frame: Change from baseline pain scores at 24 hours
Postoperative pain scores of the patients were recorded via Visual Analog Scale (VAS; 0= no pain, 10= worst pain)
morphine consumption
Time Frame: Change from baseline morphine consumption at 24 hours
At the end of surgery, patients were allowed to use the patient controlled analgesia (PCA) device. The PCA delivered bolus doses of morphine (0.02 mg/kg) every 10 minutes without a backround infusion. Morphine consumption (mg) was evaluated and recorded postoperative 24 hours.
Secondary Outcomes
- systolic arterial blood pressure(change from baseline systolic blood pressure at 150 minutes)
- diastolic arterial blood pressure(change from baseline diastolic blood pressure at 150 minutes)
- mean arterial blood pressure(change from baseline mean arterial blood pressure at 150 minutes)
- heart rate(change from baseline heart rate at 150 minutes)
- side effects(postoperative 24 hours)