Burden of Valvular Heart Diseases in an Ethnical/Racial Diverse Background of the United States: the Bronx-Valve Registry
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 330,570
- 试验地点
- 1
- 主要终点
- All-cause mortality
研究概览
简要总结
The Bronx-Valve Registry is designed to collect and assess data on all patients with valvular diseases referred to Montefiore Medical Center for echocardiographic exams. Valvular heart disease (VHD) is a major focus of cardiovascular medicine, but limited data are available for racial and ethnic minorities. The aim was to assess the burden and clinical correlates of VHD in a highly diverse area of the United States.
详细描述
Cardiovascular disease is the leading cause of death in the general US population. Although the burden of valvular heart disease is increasing due to a rapidly aging population, patients can benefit from improved and more accessible imaging modalities, and novel minimally invasive treatments. However, medical knowledge and technological developments might not be generalizable to all patient backgrounds due to lack of diversity in scientific literature.
Historically, clinical trials testing new treatment modalities have lacked equitable inclusion of people coming from racial/ethnic minority groups. Similarly, epidemiological studies have focused on specific patient subsets with no direct comparisons with the other backgrounds. The Bronx county (New York, USA) is considered by the US Census as the most diverse area in the country, having the highest overwhelming concentration of non-white populations and being the only borough in all of New York City to be almost exclusively populated by non-white enclaves. These demographic characteristics make this county ideal to assess how the prevalence and the clinical correlates of valvular heart diseases might vary among diverse populations.
On this background, the objective of this registry is to assess the burden of valvular heart diseases and explore their clinical correlates in the most diverse area of the United States.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Minimum age of 18 years old
- •Undergoing transthoracic or transesophageal echocardiographic assessment at Montefiore Medical Center or affiliated institutions in the Bronx (NY, USA)
排除标准
- •Age below 18 years old
- •No available information regarding race or ethnicity
结局指标
主要结局
All-cause mortality
时间窗: Up to 10 years
All-cause mortality according to valvular heart disease and racial/ethnical group
Racial/ethnical based differences in baseline characteristics and valvular heart disease
时间窗: Baseline
Baseline characteristics among pre-defined racial/ethnical groups will be compared for each valvular heart disease
Prevalence of Valvular Heart Disease
时间窗: Up to 10 years
Prevalence of each valvular heart disease will be compared among pre-defined racial/ethnical groups
次要结局
未报告次要终点
