Resistance Training in Knee Osteoarthritis

Phase 2

• Conditions: Knee Osteoarthritis
• Interventions: Other: exercise

• Registration Number: NCT01099371
• Lead Sponsor: Federal University of São Paulo

Brief Summary

The purpose of this study is to determine whether:

1. Progressive resistance training improves pain and disability

2. Progressive Resistance training improves muscular strength, ability to walk and quality of life

Detailed Description

Patients in experimental group participated in a 12-week progressive resistance training using a repetition maximum (RM) exercise in which patients performed 1RM with the maximum bearable weight. Once the 1RM was determined, training was divided into the following regimen: 2 series of 8 repetitions, the first with 50% and the second with 70% of 1RM.

The exercises were knee extension and flexion and hip abduction and adduction, all performed in machines. The 1RM load was reevaluated every 2 weeks.

The control group remained on a three-month waiting list for physiotherapy. Patients were assessed for pain, function, quality of life, muscle strength and six-minute walk test.

Study Timeline

• Status Verified: 2009-01
• Study Start: 2009-02
• Primary Completion: 2009-02
• Study First Submitted: 2010-04-01
• Study First Submitted QC: 2010-04-05
• Study First Posted: 2010-04-07
• Last Update Submitted: 2010-05-06
• Last Update Posted: 2010-05-07
• Study Completion: 2011-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

• Woman
• Age between 40-70 years old
• Pain between 3 and 8 on a 10-point numeric pain scale
• Radiographically confirmed knee OA

Exclusion Criteria

• Inflammatory diseases or any comorbidity that prohibit exercises, regular physical activity
• Trip plans for the next 12 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
exercise	exercise	-

Primary Outcome Measures

Name	Time	Method
Pain assessed on a 10-point numeric pain scale	week 0	Scale: visual analog scale

Secondary Outcome Measures

Name	Time	Method
Disability assessed on WOMAC	week 6	Western Ontario McMaster University Osteoarthritis Index Rheumatology An arthritic pain scoring system ranging from 0-no pain/disability to 100-most severe pain/disability; WOMAC-pain, WOMAC-function and WOMAC-stifness
Quality of life assessed on the SF-36	week 6	Questionnaire Short-form-36
Six-minute walk test	week 12	To assess distance walked in 6 minutes

Trial Locations

Locations (1)

Federal University of Sao Paulo; 🇧🇷 Sao Paulo, SP, Brazil